Misinterpretation of the mouse ECG: 'Musing the waves of Mus musculus'

Bastiaan J. Boukens, Mathilde R. Rivaud, Stacey Rentschler, Ruben Coronel

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations

Abstract

The ECG is a primary diagnostic tool in patients suffering from heart disease, underscoring the importance of understanding factors contributing to normal and abnormal electrical patterns. Over the past few decades, transgenic mouse models have been increasingly used to study pathophysiological mechanisms of human heart diseases. In order to allow extrapolation of insights gained from murine models to the human condition, knowledge of the similarities and differences between the mouse and human ECG is of crucial importance. In this review, we briefly discuss the physiologicalmechanisms underlying differences between the baseline ECG of humans and mice, and provide a framework for understanding how these inherent differences are relevant to the interpretation of the mouse ECG during pathology and to the translation of the results from the mouse to man.

Original languageEnglish
Pages (from-to)4613-4626
Number of pages14
JournalJournal of Physiology
Volume592
Issue number21
DOIs
StatePublished - Nov 1 2014

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