MiR-218 steps down to a threshold of motor impairment

Victoria A. Church, Andrew S. Yoo

Research output: Contribution to journalComment/debate

Abstract

In this issue of Neuron, Amin et al. (2021) generate genetic tools to titrate down levels of miR-218, a motor neuron-enriched microRNA, in vivo. Varying miR-218 dose alters target selection, results in distinct dose-response curves reflecting 3' UTR features, and reveals a miR-218 threshold below which motor neuron deficits emerge.

Original languageEnglish
Pages (from-to)3233-3235
Number of pages3
JournalNeuron
Volume109
Issue number20
DOIs
StatePublished - Oct 20 2021

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