MiR-218 steps down to a threshold of motor impairment

Victoria A. Church; Andrew S. Yoo

doi:10.1016/j.neuron.2021.09.030

MiR-218 steps down to a threshold of motor impairment

Victoria A. Church, Andrew S. Yoo

Research output: Contribution to journal › Article › peer-review

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Abstract

In this issue of Neuron, Amin et al. (2021) generate genetic tools to titrate down levels of miR-218, a motor neuron-enriched microRNA, in vivo. Varying miR-218 dose alters target selection, results in distinct dose-response curves reflecting 3′ UTR features, and reveals a miR-218 threshold below which motor neuron deficits emerge.

Original language	English
Pages (from-to)	3233-3235
Number of pages	3
Journal	Neuron
Volume	109
Issue number	20
DOIs	https://doi.org/10.1016/j.neuron.2021.09.030
State	Published - Oct 20 2021

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10.1016/j.neuron.2021.09.030

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title = "MiR-218 steps down to a threshold of motor impairment",

abstract = "In this issue of Neuron, Amin et al. (2021) generate genetic tools to titrate down levels of miR-218, a motor neuron-enriched microRNA, in vivo. Varying miR-218 dose alters target selection, results in distinct dose-response curves reflecting 3′ UTR features, and reveals a miR-218 threshold below which motor neuron deficits emerge.",

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MiR-218 steps down to a threshold of motor impairment

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