miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival

John D. Gagnon, Robin Kageyama, Hesham M. Shehata, Marlys S. Fassett, Darryl J. Mar, Eric J. Wigton, Kristina Johansson, Adam J. Litterman, Pamela Odorizzi, Dimitre Simeonov, Brian J. Laidlaw, Marisella Panduro, Sana Patel, Lukas T. Jeker, Margaret E. Feeney, Michael T. McManus, Alexander Marson, Mehrdad Matloubian, Shomyseh Sanjabi, K. Mark Ansel

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Coordinate control of T cell proliferation, survival, and differentiation are essential for effective cell-mediated adaptive immunity. Gagnon et al. define roles for the miR-15/16 family of microRNAs in restricting T cell cycle and long-lived memory T cell accumulation through the direct inhibition of a very large network of target mRNAs.

Original languageEnglish
Pages (from-to)2169-2181.e4
JournalCell Reports
Issue number8
StatePublished - Aug 20 2019


  • Argonaute HITS-CLIP
  • CD127
  • IL-7 receptor
  • T cell memory
  • cell cycle
  • miR-15a
  • miR-15b
  • miR-16
  • miRNA
  • microRNA


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