miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival

John D. Gagnon; Robin Kageyama; Hesham M. Shehata; Marlys S. Fassett; Darryl J. Mar; Eric J. Wigton; Kristina Johansson; Adam J. Litterman; Pamela Odorizzi; Dimitre Simeonov; Brian J. Laidlaw; Marisella Panduro; Sana Patel; Lukas T. Jeker; Margaret E. Feeney; Michael T. McManus; Alexander Marson; Mehrdad Matloubian; Shomyseh Sanjabi; K. Mark Ansel

doi:10.1016/j.celrep.2019.07.064

miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival

John D. Gagnon, Robin Kageyama, Hesham M. Shehata, Marlys S. Fassett, Darryl J. Mar, Eric J. Wigton, Kristina Johansson, Adam J. Litterman, Pamela Odorizzi, Dimitre Simeonov, Brian J. Laidlaw, Marisella Panduro, Sana Patel, Lukas T. Jeker, Margaret E. Feeney, Michael T. McManus, Alexander Marson, Mehrdad Matloubian, Shomyseh Sanjabi, K. Mark Ansel

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Coordinate control of T cell proliferation, survival, and differentiation are essential for effective cell-mediated adaptive immunity. Gagnon et al. define roles for the miR-15/16 family of microRNAs in restricting T cell cycle and long-lived memory T cell accumulation through the direct inhibition of a very large network of target mRNAs.

Original language	English
Pages (from-to)	2169-2181.e4
Journal	Cell Reports
Volume	28
Issue number	8
DOIs	https://doi.org/10.1016/j.celrep.2019.07.064
State	Published - Aug 20 2019

Keywords

Argonaute HITS-CLIP
CD127
IL-7 receptor
T cell memory
cell cycle
miR-15a
miR-15b
miR-16
miRNA
microRNA

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10.1016/j.celrep.2019.07.064

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Gagnon, J. D., Kageyama, R., Shehata, H. M., Fassett, M. S., Mar, D. J., Wigton, E. J., Johansson, K., Litterman, A. J., Odorizzi, P., Simeonov, D., Laidlaw, B. J., Panduro, M., Patel, S., Jeker, L. T., Feeney, M. E., McManus, M. T., Marson, A., Matloubian, M., Sanjabi, S., & Ansel, K. M. (2019). miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival. Cell Reports, 28(8), 2169-2181.e4. https://doi.org/10.1016/j.celrep.2019.07.064

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title = "miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival",

abstract = "Coordinate control of T cell proliferation, survival, and differentiation are essential for effective cell-mediated adaptive immunity. Gagnon et al. define roles for the miR-15/16 family of microRNAs in restricting T cell cycle and long-lived memory T cell accumulation through the direct inhibition of a very large network of target mRNAs.",

keywords = "Argonaute HITS-CLIP, CD127, IL-7 receptor, T cell memory, cell cycle, miR-15a, miR-15b, miR-16, miRNA, microRNA",

author = "Gagnon, {John D.} and Robin Kageyama and Shehata, {Hesham M.} and Fassett, {Marlys S.} and Mar, {Darryl J.} and Wigton, {Eric J.} and Kristina Johansson and Litterman, {Adam J.} and Pamela Odorizzi and Dimitre Simeonov and Laidlaw, {Brian J.} and Marisella Panduro and Sana Patel and Jeker, {Lukas T.} and Feeney, {Margaret E.} and McManus, {Michael T.} and Alexander Marson and Mehrdad Matloubian and Shomyseh Sanjabi and Ansel, {K. Mark}",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s)",

year = "2019",

month = aug,

day = "20",

doi = "10.1016/j.celrep.2019.07.064",

language = "English",

volume = "28",

pages = "2169--2181.e4",

journal = "Cell Reports",

issn = "2639-1856",

number = "8",

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Gagnon, JD, Kageyama, R, Shehata, HM, Fassett, MS, Mar, DJ, Wigton, EJ, Johansson, K, Litterman, AJ, Odorizzi, P, Simeonov, D, Laidlaw, BJ, Panduro, M, Patel, S, Jeker, LT, Feeney, ME, McManus, MT, Marson, A, Matloubian, M, Sanjabi, S & Ansel, KM 2019, 'miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival', Cell Reports, vol. 28, no. 8, pp. 2169-2181.e4. https://doi.org/10.1016/j.celrep.2019.07.064

TY - JOUR

T1 - miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival

AU - Gagnon, John D.

AU - Kageyama, Robin

AU - Shehata, Hesham M.

AU - Fassett, Marlys S.

AU - Mar, Darryl J.

AU - Wigton, Eric J.

AU - Johansson, Kristina

AU - Litterman, Adam J.

AU - Odorizzi, Pamela

AU - Simeonov, Dimitre

AU - Laidlaw, Brian J.

AU - Panduro, Marisella

AU - Patel, Sana

AU - Jeker, Lukas T.

AU - Feeney, Margaret E.

AU - McManus, Michael T.

AU - Marson, Alexander

AU - Matloubian, Mehrdad

AU - Sanjabi, Shomyseh

AU - Ansel, K. Mark

PY - 2019/8/20

Y1 - 2019/8/20

N2 - Coordinate control of T cell proliferation, survival, and differentiation are essential for effective cell-mediated adaptive immunity. Gagnon et al. define roles for the miR-15/16 family of microRNAs in restricting T cell cycle and long-lived memory T cell accumulation through the direct inhibition of a very large network of target mRNAs.

AB - Coordinate control of T cell proliferation, survival, and differentiation are essential for effective cell-mediated adaptive immunity. Gagnon et al. define roles for the miR-15/16 family of microRNAs in restricting T cell cycle and long-lived memory T cell accumulation through the direct inhibition of a very large network of target mRNAs.

KW - Argonaute HITS-CLIP

KW - CD127

KW - IL-7 receptor

KW - T cell memory

KW - cell cycle

KW - miR-15a

KW - miR-15b

KW - miR-16

KW - miRNA

KW - microRNA

UR - http://www.scopus.com/inward/record.url?scp=85070538604&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2019.07.064

DO - 10.1016/j.celrep.2019.07.064

M3 - Article

C2 - 31433990

AN - SCOPUS:85070538604

SN - 2639-1856

VL - 28

SP - 2169-2181.e4

JO - Cell Reports

JF - Cell Reports

IS - 8

ER -

miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival

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Keywords

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