miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival

John D. Gagnon, Robin Kageyama, Hesham M. Shehata, Marlys S. Fassett, Darryl J. Mar, Eric J. Wigton, Kristina Johansson, Adam J. Litterman, Pamela Odorizzi, Dimitre Simeonov, Brian J. Laidlaw, Marisella Panduro, Sana Patel, Lukas T. Jeker, Margaret E. Feeney, Michael T. McManus, Alexander Marson, Mehrdad Matloubian, Shomyseh Sanjabi, K. Mark Ansel

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Coordinate control of T cell proliferation, survival, and differentiation are essential for effective cell-mediated adaptive immunity. Gagnon et al. define roles for the miR-15/16 family of microRNAs in restricting T cell cycle and long-lived memory T cell accumulation through the direct inhibition of a very large network of target mRNAs.

Original languageEnglish
Pages (from-to)2169-2181.e4
JournalCell Reports
Volume28
Issue number8
DOIs
StatePublished - Aug 20 2019

Keywords

  • Argonaute HITS-CLIP
  • CD127
  • IL-7 receptor
  • T cell memory
  • cell cycle
  • miR-15a
  • miR-15b
  • miR-16
  • miRNA
  • microRNA

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