@article{6ebcbe1c2c1f4cbcba6b42698200723b,
title = "MiR-146a and miR-155 delineate a microRNA fingerprint associated with toxoplasma persistence in the host brain",
abstract = "microRNAs were recently found to be regulators of the host response to infection by apicomplexan parasites. In this study, we identified two immunomodulatory microRNAs, miR-146a and miR-155, that werecoinduced in the brains of mice challenged with Toxoplasma in a strain-specific manner. These microRNAs define a characteristic fingerprint for infection by type II strains, which are the most prevalent cause of human toxoplasmosis in Europe and North America. Using forward genetics, we showed that strain-specific differences in miR-146a modulation were in part mediated by the rhoptry kinase, ROP16. Remarkably, we found that miR-146a deficiency led to better control of parasite burden in the gut and most likely of early parasite dissemination in the brain tissue, resulting in the long-term survival of mice.",
author = "Dominique Cannella and Brenier-Pinchart, \{Marie Pierre\} and Laurence Braun and vanRooyen, \{Jason M.\} and Alexandre Bougdour and Olivier Bastien and Behnke, \{Michael S.\} and Curt, \{Rose Laurence\} and Aur{\'e}lie Curt and Saeij, \{Jeroen P.J.\} and Sibley, \{L. David\} and Herv{\'e} Pelloux and Hakimi, \{Mohamed Ali\}",
note = "Funding Information: We thank Pr. Sylvie Lantuejoul and Dr. Philippe Lorimier (CHU, Grenoble) for their help on brain pathology analysis. We thank Bastien Touquet for his technical help. This work was supported by ANR Blanc 2010 grant APImiR (ANR 2010 BLAN 1315 01), ANR blanc ToxoHDAC (ANR-12-BSV3-0009-01), and the LabEx ParaFrap (ANR-11-LABX-0024). J.P.J.S. was supported by National Institutes of Health R01-AI080621. ",
year = "2014",
doi = "10.1016/j.celrep.2014.02.002",
language = "English",
volume = "6",
pages = "928--937",
journal = "Cell Reports",
issn = "2639-1856",
number = "5",
}