MiR-146a and miR-155 delineate a microRNA fingerprint associated with toxoplasma persistence in the host brain

Dominique Cannella; Marie Pierre Brenier-Pinchart; Laurence Braun; Jason M. vanRooyen; Alexandre Bougdour; Olivier Bastien; Michael S. Behnke; Rose Laurence Curt; Aurélie Curt; Jeroen P.J. Saeij; L. David Sibley; Hervé Pelloux; Mohamed Ali Hakimi

doi:10.1016/j.celrep.2014.02.002

MiR-146a and miR-155 delineate a microRNA fingerprint associated with toxoplasma persistence in the host brain

Dominique Cannella, Marie Pierre Brenier-Pinchart, Laurence Braun, Jason M. vanRooyen, Alexandre Bougdour, Olivier Bastien, Michael S. Behnke, Rose Laurence Curt, Aurélie Curt, Jeroen P.J. Saeij, L. David Sibley, Hervé Pelloux, Mohamed Ali Hakimi

Research output: Contribution to journal › Article

39 Scopus citations

Abstract

microRNAs were recently found to be regulators of the host response to infection by apicomplexan parasites. In this study, we identified two immunomodulatory microRNAs, miR-146a and miR-155, that werecoinduced in the brains of mice challenged with Toxoplasma in a strain-specific manner. These microRNAs define a characteristic fingerprint for infection by type II strains, which are the most prevalent cause of human toxoplasmosis in Europe and North America. Using forward genetics, we showed that strain-specific differences in miR-146a modulation were in part mediated by the rhoptry kinase, ROP16. Remarkably, we found that miR-146a deficiency led to better control of parasite burden in the gut and most likely of early parasite dissemination in the brain tissue, resulting in the long-term survival of mice.

Original language	English
Pages (from-to)	928-937
Number of pages	10
Journal	Cell Reports
Volume	6
Issue number	5
DOIs	https://doi.org/10.1016/j.celrep.2014.02.002
State	Published - Jan 1 2014

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Cannella, D., Brenier-Pinchart, M. P., Braun, L., vanRooyen, J. M., Bougdour, A., Bastien, O., Behnke, M. S., Curt, R. L., Curt, A., Saeij, J. P. J., Sibley, L. D., Pelloux, H., & Hakimi, M. A. (2014). MiR-146a and miR-155 delineate a microRNA fingerprint associated with toxoplasma persistence in the host brain. Cell Reports, 6(5), 928-937. https://doi.org/10.1016/j.celrep.2014.02.002

Cannella, Dominique ; Brenier-Pinchart, Marie Pierre ; Braun, Laurence ; vanRooyen, Jason M. ; Bougdour, Alexandre ; Bastien, Olivier ; Behnke, Michael S. ; Curt, Rose Laurence ; Curt, Aurélie ; Saeij, Jeroen P.J. ; Sibley, L. David ; Pelloux, Hervé ; Hakimi, Mohamed Ali. / MiR-146a and miR-155 delineate a microRNA fingerprint associated with toxoplasma persistence in the host brain. In: Cell Reports. 2014 ; Vol. 6, No. 5. pp. 928-937.

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title = "MiR-146a and miR-155 delineate a microRNA fingerprint associated with toxoplasma persistence in the host brain",

abstract = "microRNAs were recently found to be regulators of the host response to infection by apicomplexan parasites. In this study, we identified two immunomodulatory microRNAs, miR-146a and miR-155, that werecoinduced in the brains of mice challenged with Toxoplasma in a strain-specific manner. These microRNAs define a characteristic fingerprint for infection by type II strains, which are the most prevalent cause of human toxoplasmosis in Europe and North America. Using forward genetics, we showed that strain-specific differences in miR-146a modulation were in part mediated by the rhoptry kinase, ROP16. Remarkably, we found that miR-146a deficiency led to better control of parasite burden in the gut and most likely of early parasite dissemination in the brain tissue, resulting in the long-term survival of mice.",

author = "Dominique Cannella and Brenier-Pinchart, {Marie Pierre} and Laurence Braun and vanRooyen, {Jason M.} and Alexandre Bougdour and Olivier Bastien and Behnke, {Michael S.} and Curt, {Rose Laurence} and Aur{\'e}lie Curt and Saeij, {Jeroen P.J.} and Sibley, {L. David} and Herv{\'e} Pelloux and Hakimi, {Mohamed Ali}",

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doi = "10.1016/j.celrep.2014.02.002",

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Cannella, D, Brenier-Pinchart, MP, Braun, L, vanRooyen, JM, Bougdour, A, Bastien, O, Behnke, MS, Curt, RL, Curt, A, Saeij, JPJ, Sibley, LD, Pelloux, H & Hakimi, MA 2014, 'MiR-146a and miR-155 delineate a microRNA fingerprint associated with toxoplasma persistence in the host brain', Cell Reports, vol. 6, no. 5, pp. 928-937. https://doi.org/10.1016/j.celrep.2014.02.002

MiR-146a and miR-155 delineate a microRNA fingerprint associated with toxoplasma persistence in the host brain. / Cannella, Dominique; Brenier-Pinchart, Marie Pierre; Braun, Laurence; vanRooyen, Jason M.; Bougdour, Alexandre; Bastien, Olivier; Behnke, Michael S.; Curt, Rose Laurence; Curt, Aurélie; Saeij, Jeroen P.J.; Sibley, L. David; Pelloux, Hervé; Hakimi, Mohamed Ali.

In: Cell Reports, Vol. 6, No. 5, 01.01.2014, p. 928-937.

Research output: Contribution to journal › Article

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AU - Cannella, Dominique

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AU - Braun, Laurence

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AU - Bougdour, Alexandre

AU - Bastien, Olivier

AU - Behnke, Michael S.

AU - Curt, Rose Laurence

AU - Curt, Aurélie

AU - Saeij, Jeroen P.J.

AU - Sibley, L. David

AU - Pelloux, Hervé

AU - Hakimi, Mohamed Ali

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AB - microRNAs were recently found to be regulators of the host response to infection by apicomplexan parasites. In this study, we identified two immunomodulatory microRNAs, miR-146a and miR-155, that werecoinduced in the brains of mice challenged with Toxoplasma in a strain-specific manner. These microRNAs define a characteristic fingerprint for infection by type II strains, which are the most prevalent cause of human toxoplasmosis in Europe and North America. Using forward genetics, we showed that strain-specific differences in miR-146a modulation were in part mediated by the rhoptry kinase, ROP16. Remarkably, we found that miR-146a deficiency led to better control of parasite burden in the gut and most likely of early parasite dissemination in the brain tissue, resulting in the long-term survival of mice.

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