TY - JOUR
T1 - MIPS
T2 - Analysis and annotation of genome information in 2007
AU - Mewes, H. W.
AU - Dietmann, S.
AU - Frishman, D.
AU - Gregory, R.
AU - Mannhaupt, G.
AU - Mayer, K. F.X.
AU - Münsterkötter, M.
AU - Ruepp, A.
AU - Spannagl, M.
AU - Stümpflen, V.
AU - Rattei, T.
N1 - Funding Information:
This work was supported by the Federal Ministry of Education, Science, Research and Technology (BMBF: BFAM: 031U112C, GABI: 0312270/4, NGFN: 01KW9710), the Deutsche Forschungsge-meinschaft (Bioinformatics Munich, BIM), and the Max-Planck-Society (MUMDB). We thank Biomax Informatics AG for providing the PEDANT Genome Annotation System. Funding to pay the Open Access publication charges for this article was provided by the GSF—National Research Center for Environment and Health.
PY - 2008/1
Y1 - 2008/1
N2 - The Munich Information Center for Protein Sequences (MIPS-GSF, Neuherberg, Germany) combines automatic processing of large amounts of sequences with manual annotation of selected model genomes. Due to the massive growth of the available data, the depth of annotation varies widely between independent databases. Also, the criteria for the transfer of information from known to orthologous sequences are diverse. To cope with the task of global in-depth genome annotation has become unfeasible. Therefore, our efforts are dedicated to three levels of annotation: (i) the curation of selected genomes, in particular from fungal and plant taxa (e.g. CYGD, MNCDB, MatDB), (ii) the comprehensive, consistent, automatic annotation employing exhaustive methods for the computation of sequence similarities and sequence-related attributes as well as the classification of individual sequences (SIMAP, PEDANT and FunCat) and (iii) the compilation of manually curated databases for protein interactions based on scrutinized information from the literature to serve as an accepted set of reliable annotated interaction data (MPACT, MPPI, CORUM). All databases and tools described as well as the detailed descriptions of our projects can be accessed through the MIPS web server (http://mips.gsf.de).
AB - The Munich Information Center for Protein Sequences (MIPS-GSF, Neuherberg, Germany) combines automatic processing of large amounts of sequences with manual annotation of selected model genomes. Due to the massive growth of the available data, the depth of annotation varies widely between independent databases. Also, the criteria for the transfer of information from known to orthologous sequences are diverse. To cope with the task of global in-depth genome annotation has become unfeasible. Therefore, our efforts are dedicated to three levels of annotation: (i) the curation of selected genomes, in particular from fungal and plant taxa (e.g. CYGD, MNCDB, MatDB), (ii) the comprehensive, consistent, automatic annotation employing exhaustive methods for the computation of sequence similarities and sequence-related attributes as well as the classification of individual sequences (SIMAP, PEDANT and FunCat) and (iii) the compilation of manually curated databases for protein interactions based on scrutinized information from the literature to serve as an accepted set of reliable annotated interaction data (MPACT, MPPI, CORUM). All databases and tools described as well as the detailed descriptions of our projects can be accessed through the MIPS web server (http://mips.gsf.de).
UR - http://www.scopus.com/inward/record.url?scp=38549170927&partnerID=8YFLogxK
U2 - 10.1093/nar/gkm980
DO - 10.1093/nar/gkm980
M3 - Article
C2 - 18158298
AN - SCOPUS:38549170927
SN - 0305-1048
VL - 36
SP - D196-D201
JO - Nucleic acids research
JF - Nucleic acids research
IS - SUPPL. 1
ER -