Minimal connectivity between six month neostriatal transplants and the host substantia nigra

James P. McAllister; Sheldon R. Cober; Eric R. Schaible; Paul D. Walker

doi:10.1016/0006-8993(89)91256-0

Minimal connectivity between six month neostriatal transplants and the host substantia nigra

James P. McAllister, Sheldon R. Cober, Eric R. Schaible, Paul D. Walker

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The present study sought to determine if axonal connectivity is established between 6-month-old neostriatal transplants and the host substantia nigra. Cell suspensions of fetal neostriatum were transplanted into the adult rat neostriatum lesioned previously by kainic acid. Horseradish peroxidase injections into the ipsilateral ventral midbrain labelled the lesion site and the intact neostriatum extensively, but no appreciable anterograde or retrograde label was found within the graft. These results demonstrate a paucity of connectivity between neostriatal grafts and the host brain at a time when other investigators have described transplant-mediated recovery of function.

Original language	English
Pages (from-to)	345-350
Number of pages	6
Journal	Brain Research
Volume	476
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(89)91256-0
State	Published - Jan 9 1989

Keywords

Connectivity
Horseradish peroxidase
Huntington's disease
Neostriatum
Neural grafting
Rat
Substantia nigra

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title = "Minimal connectivity between six month neostriatal transplants and the host substantia nigra",

abstract = "The present study sought to determine if axonal connectivity is established between 6-month-old neostriatal transplants and the host substantia nigra. Cell suspensions of fetal neostriatum were transplanted into the adult rat neostriatum lesioned previously by kainic acid. Horseradish peroxidase injections into the ipsilateral ventral midbrain labelled the lesion site and the intact neostriatum extensively, but no appreciable anterograde or retrograde label was found within the graft. These results demonstrate a paucity of connectivity between neostriatal grafts and the host brain at a time when other investigators have described transplant-mediated recovery of function.",

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AU - Cober, Sheldon R.

AU - Schaible, Eric R.

AU - Walker, Paul D.

PY - 1989/1/9

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N2 - The present study sought to determine if axonal connectivity is established between 6-month-old neostriatal transplants and the host substantia nigra. Cell suspensions of fetal neostriatum were transplanted into the adult rat neostriatum lesioned previously by kainic acid. Horseradish peroxidase injections into the ipsilateral ventral midbrain labelled the lesion site and the intact neostriatum extensively, but no appreciable anterograde or retrograde label was found within the graft. These results demonstrate a paucity of connectivity between neostriatal grafts and the host brain at a time when other investigators have described transplant-mediated recovery of function.

AB - The present study sought to determine if axonal connectivity is established between 6-month-old neostriatal transplants and the host substantia nigra. Cell suspensions of fetal neostriatum were transplanted into the adult rat neostriatum lesioned previously by kainic acid. Horseradish peroxidase injections into the ipsilateral ventral midbrain labelled the lesion site and the intact neostriatum extensively, but no appreciable anterograde or retrograde label was found within the graft. These results demonstrate a paucity of connectivity between neostriatal grafts and the host brain at a time when other investigators have described transplant-mediated recovery of function.

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KW - Horseradish peroxidase

KW - Huntington's disease

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KW - Neural grafting

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Minimal connectivity between six month neostriatal transplants and the host substantia nigra

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