TY - JOUR
T1 - Minimal-change nephrotic syndrome in a hematopoietic stem-cell transplant recipient
AU - Humphreys, Benjamin D.
AU - Vanguri, Vijay K.
AU - Henderson, Joel
AU - Antin, Joseph H.
PY - 2006/9/4
Y1 - 2006/9/4
N2 - Background: A 61-year-old woman received standard immunizations, including Haemophilus influenzae type B, diphtheria, tetanus toxoid, and unconjugated 23-valent pneumococcal vaccine (Pneumovax®, Merck & Co., Inc., Whitehouse Station, NJ), 1 year after undergoing nonmyeloablative hematopoietic stem-cell transplantation for acute myelogenous leukemia. After 5 days, she developed fatigue with progressive weight gain and edema, and 14 days after immunization she presented with anasarca and was found to have acute renal failure and nephrotic proteinuria. Investigations: Physical examination, serum chemistry, examination of urine sediment, renal ultrasound using Doppler scanning, 24 h urine collection, and renal biopsy. Diagnosis: Minimal-change nephrotic syndrome with acute tubular injury. Management: Aggressive diuresis and oral corticosteroid therapy.
AB - Background: A 61-year-old woman received standard immunizations, including Haemophilus influenzae type B, diphtheria, tetanus toxoid, and unconjugated 23-valent pneumococcal vaccine (Pneumovax®, Merck & Co., Inc., Whitehouse Station, NJ), 1 year after undergoing nonmyeloablative hematopoietic stem-cell transplantation for acute myelogenous leukemia. After 5 days, she developed fatigue with progressive weight gain and edema, and 14 days after immunization she presented with anasarca and was found to have acute renal failure and nephrotic proteinuria. Investigations: Physical examination, serum chemistry, examination of urine sediment, renal ultrasound using Doppler scanning, 24 h urine collection, and renal biopsy. Diagnosis: Minimal-change nephrotic syndrome with acute tubular injury. Management: Aggressive diuresis and oral corticosteroid therapy.
KW - Acute renal failure
KW - Bone-marrow transplant
KW - Immunization
KW - Minimal-change disease
KW - Nephrotic syndrome
UR - http://www.scopus.com/inward/record.url?scp=33748306078&partnerID=8YFLogxK
U2 - 10.1038/ncpneph0271
DO - 10.1038/ncpneph0271
M3 - Article
C2 - 16941046
AN - SCOPUS:33748306078
SN - 1745-8323
VL - 2
SP - 535
EP - 539
JO - Nature Clinical Practice Nephrology
JF - Nature Clinical Practice Nephrology
IS - 9
ER -