Minimal-change nephrotic syndrome in a hematopoietic stem-cell transplant recipient

Benjamin D. Humphreys, Vijay K. Vanguri, Joel Henderson, Joseph H. Antin

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Background: A 61-year-old woman received standard immunizations, including Haemophilus influenzae type B, diphtheria, tetanus toxoid, and unconjugated 23-valent pneumococcal vaccine (Pneumovax®, Merck & Co., Inc., Whitehouse Station, NJ), 1 year after undergoing nonmyeloablative hematopoietic stem-cell transplantation for acute myelogenous leukemia. After 5 days, she developed fatigue with progressive weight gain and edema, and 14 days after immunization she presented with anasarca and was found to have acute renal failure and nephrotic proteinuria. Investigations: Physical examination, serum chemistry, examination of urine sediment, renal ultrasound using Doppler scanning, 24 h urine collection, and renal biopsy. Diagnosis: Minimal-change nephrotic syndrome with acute tubular injury. Management: Aggressive diuresis and oral corticosteroid therapy.

Original languageEnglish
Pages (from-to)535-539
Number of pages5
JournalNature Clinical Practice Nephrology
Issue number9
StatePublished - Sep 4 2006


  • Acute renal failure
  • Bone-marrow transplant
  • Immunization
  • Minimal-change disease
  • Nephrotic syndrome


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