Minimal activity of nanoparticle albumin-bound (nab) paclitaxel in relapsed or refractory lymphomas: results of a phase-I study

Sagun Goyal, Eunhye Oak, Jingqin Luo, Amanda F. Cashen, Kenneth Carson, Todd Fehniger, John DiPersio, Nancy L. Bartlett, Nina D. Wagner-Johnston

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Compared with solvent-based taxanes, nanoparticle albumin-bound (nab®) paclitaxel has demonstrated improved efficacy and tolerability in several solid tumor malignancies. Studies evaluating nab paclitaxel in patients with lymphoma are lacking. In this planned phase-I/phase-II study, we sought to determine the safety and efficacy of nab-paclitaxel in patients with relapsed/refractory (R/R) lymphoma. Eligible patients (R/R to ≥2 prior systemic therapies) received weekly nab-paclitaxel on days 1, 8 and 15 every 28 days. Dosing was initiated at 100 mg/m2 with dose escalations in 25 mg/m2 increments up to 150 mg/m2 in a classic 3 + 3 design. Twenty heavily pretreated patients (median 5 prior regimens), including 65% with refractory disease, enrolled. The maximum dose tested was well tolerated and grade 3/4 hematologic adverse events (neutropenia 25%, thrombocytopenia 20% and anemia 15%) were modest. The overall response rate was 10% with two partial responses, leading to a decision to close the study prematurely.

Original languageEnglish
Pages (from-to)357-362
Number of pages6
JournalLeukemia and Lymphoma
Volume59
Issue number2
DOIs
StatePublished - Feb 1 2018

Keywords

  • Nab paclitaxel
  • lymphoma and Hodgkin disease
  • phase-1 study
  • sparc

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