TY - JOUR
T1 - Mindfulness-Based Stress Reduction for Symptom Management in Older Individuals with HIV-Associated Neurocognitive Disorder
AU - Moskowitz, Judith T.
AU - Sharma, Brijesh
AU - Javandel, Shireen
AU - Moran, Patricia
AU - Paul, Robert
AU - De Gruttola, Victor
AU - Tomov, Dimitre
AU - Azmy, Haleem
AU - Sandoval, Rodrigo
AU - Hillis, Madeline
AU - Chen, Karen P.
AU - Tsuei, Torie
AU - Addington, Elizabeth L.
AU - Cummings, Peter D.
AU - Hellmuth, Joanna
AU - Allen, Isabel Elaine
AU - Ances, Beau M.
AU - Valcour, Victor
AU - Milanini, Benedetta
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
PY - 2024/6
Y1 - 2024/6
N2 - The growing number of people aging with HIV represents a group vulnerable to the symptom burdens of HIV-associated neurocognitive disorder (HAND). Among younger groups, Mindfulness-Based Stress Reduction (MBSR) has been shown to help people living with HIV manage HIV-related and other life stress, and although there is some theoretical and empirical evidence that it may be effective among those with cognitive deficits, the approach has not been studied in older populations with HAND. Participants (n = 180) 55 years or older with HIV and cognitive impairment were randomly assigned to either an 8-week MBSR arm or a waitlist control. We assessed the impact of MBSR compared to a waitlist control on psychological outcomes [stress, anxiety, depression, and quality of life (QOL)] and cognitive metrics (e.g., speed of information processing, working memory, attention, impulsivity) measured at baseline, immediately post intervention (8 weeks) and one month later (16 weeks). Intent to treat analyses showed significant improvement in the MBSR group compared to control on symptoms of depression from baseline to 8 weeks, however, the difference was not sustained at 16 weeks. The MBSR group also showed improvement in perceived QOL from baseline to 16 weeks compared to the waitlist control group. Cognitive performance did not differ between the two treatment arms. MBSR shows promise as a tool to help alleviate the symptom burden of depression and low QOL in older individuals living with HAND and future work should address methods to better sustain the beneficial impact on depression and QOL.
AB - The growing number of people aging with HIV represents a group vulnerable to the symptom burdens of HIV-associated neurocognitive disorder (HAND). Among younger groups, Mindfulness-Based Stress Reduction (MBSR) has been shown to help people living with HIV manage HIV-related and other life stress, and although there is some theoretical and empirical evidence that it may be effective among those with cognitive deficits, the approach has not been studied in older populations with HAND. Participants (n = 180) 55 years or older with HIV and cognitive impairment were randomly assigned to either an 8-week MBSR arm or a waitlist control. We assessed the impact of MBSR compared to a waitlist control on psychological outcomes [stress, anxiety, depression, and quality of life (QOL)] and cognitive metrics (e.g., speed of information processing, working memory, attention, impulsivity) measured at baseline, immediately post intervention (8 weeks) and one month later (16 weeks). Intent to treat analyses showed significant improvement in the MBSR group compared to control on symptoms of depression from baseline to 8 weeks, however, the difference was not sustained at 16 weeks. The MBSR group also showed improvement in perceived QOL from baseline to 16 weeks compared to the waitlist control group. Cognitive performance did not differ between the two treatment arms. MBSR shows promise as a tool to help alleviate the symptom burden of depression and low QOL in older individuals living with HAND and future work should address methods to better sustain the beneficial impact on depression and QOL.
KW - Aging
KW - Cognition
KW - HIV
KW - HIV-associated neurocognitive disorder
KW - Mindfulness Based Stress Reduction
UR - http://www.scopus.com/inward/record.url?scp=85187949897&partnerID=8YFLogxK
U2 - 10.1007/s10461-024-04295-1
DO - 10.1007/s10461-024-04295-1
M3 - Article
C2 - 38493283
AN - SCOPUS:85187949897
SN - 1090-7165
VL - 28
SP - 1811
EP - 1821
JO - AIDS and Behavior
JF - AIDS and Behavior
IS - 6
ER -