Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin

Michael J. Bannon; Ariel Y. Deutch; See Ying Tam; Nadav Zamir; Robert L. Eskay; Jin Moo Lee; John E. Maggio; Robert H. Roth

doi:10.1016/0006-8993(86)90097-1

Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin

Michael J. Bannon
, Ariel Y. Deutch
, See Ying Tam
, Nadav Zamir
, Robert L. Eskay
, Jin Moo Lee
, John E. Maggio
, Robert H. Roth

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Mild footshock stress selectively activates ventral tegmental area dopamine neurons innervating the prefrontal cortex. The same stressor rapidly dissociates ventral tegmental substance P from its preprotachykinin-derived co-transmitter substance K, and preproenkephalin B-derived dynorphin B from preproenkephalin A-derived Met-enkephalin-Arg-Gly-Leu and Leu-enkephalin. Mild footshock stress may provide a paradigm for studying both peptidergic modulation of brain dopaminergic neurons and the dynamic regulation of tachykinin and opioid peptide transcription, processing and utilization.

Original language	English
Pages (from-to)	393-396
Number of pages	4
Journal	Brain Research
Volume	381
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(86)90097-1
State	Published - Sep 3 1986

Keywords

Leu-enkephalin
Met-enkephalin
footshock stress
neuromedin K
substance K
substance P
ventral tegmental area

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10.1016/0006-8993(86)90097-1

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title = "Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin",

abstract = "Mild footshock stress selectively activates ventral tegmental area dopamine neurons innervating the prefrontal cortex. The same stressor rapidly dissociates ventral tegmental substance P from its preprotachykinin-derived co-transmitter substance K, and preproenkephalin B-derived dynorphin B from preproenkephalin A-derived Met-enkephalin-Arg-Gly-Leu and Leu-enkephalin. Mild footshock stress may provide a paradigm for studying both peptidergic modulation of brain dopaminergic neurons and the dynamic regulation of tachykinin and opioid peptide transcription, processing and utilization.",

keywords = "Leu-enkephalin, Met-enkephalin, footshock stress, neuromedin K, substance K, substance P, ventral tegmental area",

author = "Bannon, \{Michael J.\} and Deutch, \{Ariel Y.\} and Tam, \{See Ying\} and Nadav Zamir and Eskay, \{Robert L.\} and Lee, \{Jin Moo\} and Maggio, \{John E.\} and Roth, \{Robert H.\}",

year = "1986",

month = sep,

day = "3",

doi = "10.1016/0006-8993(86)90097-1",

language = "English",

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journal = "Brain Research",

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TY - JOUR

T1 - Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin

AU - Bannon, Michael J.

AU - Deutch, Ariel Y.

AU - Tam, See Ying

AU - Zamir, Nadav

AU - Eskay, Robert L.

AU - Lee, Jin Moo

AU - Maggio, John E.

AU - Roth, Robert H.

PY - 1986/9/3

Y1 - 1986/9/3

N2 - Mild footshock stress selectively activates ventral tegmental area dopamine neurons innervating the prefrontal cortex. The same stressor rapidly dissociates ventral tegmental substance P from its preprotachykinin-derived co-transmitter substance K, and preproenkephalin B-derived dynorphin B from preproenkephalin A-derived Met-enkephalin-Arg-Gly-Leu and Leu-enkephalin. Mild footshock stress may provide a paradigm for studying both peptidergic modulation of brain dopaminergic neurons and the dynamic regulation of tachykinin and opioid peptide transcription, processing and utilization.

AB - Mild footshock stress selectively activates ventral tegmental area dopamine neurons innervating the prefrontal cortex. The same stressor rapidly dissociates ventral tegmental substance P from its preprotachykinin-derived co-transmitter substance K, and preproenkephalin B-derived dynorphin B from preproenkephalin A-derived Met-enkephalin-Arg-Gly-Leu and Leu-enkephalin. Mild footshock stress may provide a paradigm for studying both peptidergic modulation of brain dopaminergic neurons and the dynamic regulation of tachykinin and opioid peptide transcription, processing and utilization.

KW - Leu-enkephalin

KW - Met-enkephalin

KW - footshock stress

KW - neuromedin K

KW - substance K

KW - substance P

KW - ventral tegmental area

UR - https://www.scopus.com/pages/publications/0022495668

U2 - 10.1016/0006-8993(86)90097-1

DO - 10.1016/0006-8993(86)90097-1

M3 - Article

C2 - 2428438

AN - SCOPUS:0022495668

SN - 0006-8993

VL - 381

SP - 393

EP - 396

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin

Abstract

Keywords

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