Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin

Michael J. Bannon; Ariel Y. Deutch; See Ying Tam; Nadav Zamir; Robert L. Eskay; Jin Moo Lee; John E. Maggio; Robert H. Roth

doi:10.1016/0006-8993(86)90097-1

Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin

Michael J. Bannon, Ariel Y. Deutch, See Ying Tam, Nadav Zamir, Robert L. Eskay, Jin Moo Lee, John E. Maggio, Robert H. Roth

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Mild footshock stress selectively activates ventral tegmental area dopamine neurons innervating the prefrontal cortex. The same stressor rapidly dissociates ventral tegmental substance P from its preprotachykinin-derived co-transmitter substance K, and preproenkephalin B-derived dynorphin B from preproenkephalin A-derived Met-enkephalin-Arg-Gly-Leu and Leu-enkephalin. Mild footshock stress may provide a paradigm for studying both peptidergic modulation of brain dopaminergic neurons and the dynamic regulation of tachykinin and opioid peptide transcription, processing and utilization.

Original language	English
Pages (from-to)	393-396
Number of pages	4
Journal	Brain Research
Volume	381
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(86)90097-1
State	Published - Sep 3 1986

Keywords

Leu-enkephalin
Met-enkephalin
footshock stress
neuromedin K
substance K
substance P
ventral tegmental area

Access to Document

10.1016/0006-8993(86)90097-1

Cite this

@article{ceafa97f924842b587f18f2f2f49c1aa,

title = "Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin",

abstract = "Mild footshock stress selectively activates ventral tegmental area dopamine neurons innervating the prefrontal cortex. The same stressor rapidly dissociates ventral tegmental substance P from its preprotachykinin-derived co-transmitter substance K, and preproenkephalin B-derived dynorphin B from preproenkephalin A-derived Met-enkephalin-Arg-Gly-Leu and Leu-enkephalin. Mild footshock stress may provide a paradigm for studying both peptidergic modulation of brain dopaminergic neurons and the dynamic regulation of tachykinin and opioid peptide transcription, processing and utilization.",

keywords = "Leu-enkephalin, Met-enkephalin, footshock stress, neuromedin K, substance K, substance P, ventral tegmental area",

author = "Bannon, {Michael J.} and Deutch, {Ariel Y.} and Tam, {See Ying} and Nadav Zamir and Eskay, {Robert L.} and Lee, {Jin Moo} and Maggio, {John E.} and Roth, {Robert H.}",

year = "1986",

month = sep,

day = "3",

doi = "10.1016/0006-8993(86)90097-1",

language = "English",

volume = "381",

pages = "393--396",

journal = "Brain Research",

issn = "0006-8993",

number = "2",

}

TY - JOUR

T1 - Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin

AU - Bannon, Michael J.

AU - Deutch, Ariel Y.

AU - Tam, See Ying

AU - Zamir, Nadav

AU - Eskay, Robert L.

AU - Lee, Jin Moo

AU - Maggio, John E.

AU - Roth, Robert H.

PY - 1986/9/3

Y1 - 1986/9/3

N2 - Mild footshock stress selectively activates ventral tegmental area dopamine neurons innervating the prefrontal cortex. The same stressor rapidly dissociates ventral tegmental substance P from its preprotachykinin-derived co-transmitter substance K, and preproenkephalin B-derived dynorphin B from preproenkephalin A-derived Met-enkephalin-Arg-Gly-Leu and Leu-enkephalin. Mild footshock stress may provide a paradigm for studying both peptidergic modulation of brain dopaminergic neurons and the dynamic regulation of tachykinin and opioid peptide transcription, processing and utilization.

AB - Mild footshock stress selectively activates ventral tegmental area dopamine neurons innervating the prefrontal cortex. The same stressor rapidly dissociates ventral tegmental substance P from its preprotachykinin-derived co-transmitter substance K, and preproenkephalin B-derived dynorphin B from preproenkephalin A-derived Met-enkephalin-Arg-Gly-Leu and Leu-enkephalin. Mild footshock stress may provide a paradigm for studying both peptidergic modulation of brain dopaminergic neurons and the dynamic regulation of tachykinin and opioid peptide transcription, processing and utilization.

KW - Leu-enkephalin

KW - Met-enkephalin

KW - footshock stress

KW - neuromedin K

KW - substance K

KW - substance P

KW - ventral tegmental area

UR - http://www.scopus.com/inward/record.url?scp=0022495668&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(86)90097-1

DO - 10.1016/0006-8993(86)90097-1

M3 - Article

C2 - 2428438

AN - SCOPUS:0022495668

VL - 381

SP - 393

EP - 396

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -

Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this