Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin

Michael J. Bannon, Ariel Y. Deutch, See Ying Tam, Nadav Zamir, Robert L. Eskay, Jin Moo Lee, John E. Maggio, Robert H. Roth

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Mild footshock stress selectively activates ventral tegmental area dopamine neurons innervating the prefrontal cortex. The same stressor rapidly dissociates ventral tegmental substance P from its preprotachykinin-derived co-transmitter substance K, and preproenkephalin B-derived dynorphin B from preproenkephalin A-derived Met-enkephalin-Arg-Gly-Leu and Leu-enkephalin. Mild footshock stress may provide a paradigm for studying both peptidergic modulation of brain dopaminergic neurons and the dynamic regulation of tachykinin and opioid peptide transcription, processing and utilization.

Original languageEnglish
Pages (from-to)393-396
Number of pages4
JournalBrain Research
Volume381
Issue number2
DOIs
StatePublished - Sep 3 1986

Keywords

  • Leu-enkephalin
  • Met-enkephalin
  • footshock stress
  • neuromedin K
  • substance K
  • substance P
  • ventral tegmental area

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