TY - JOUR
T1 - Mild behavioral impairment and its relationship to cognition in community-dwelling older adults from the Boston Latino Aging Study
AU - Alcina, Jorge
AU - Munera, Diana
AU - Martinez, Lusiana
AU - Giudicessi, Averi
AU - Bonillas Félix, Nikole A.
AU - Medrano, Randy
AU - Martinez, Jairo E.
AU - Solis, Isabel
AU - Tristão-Pereira, Catarina
AU - Malotaux, Vincent
AU - He, Bing
AU - Ribas, Alexandre
AU - Ramirez, Nadeshka J.
AU - Ramirez-Gomez, Liliana A.
AU - Vila-Castelar, Clara
AU - Gonzalez Catalan, Marta
AU - Saldana, Daniel G.
AU - Gatchel, Jennifer R.
AU - Quiroz, Yakeel T.
N1 - Publisher Copyright:
© 2025 The Author(s). Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.
PY - 2025/4/1
Y1 - 2025/4/1
N2 - Background: Mild behavioral impairment (MBI) is associated with cognitive decline and dementia risk. This study assessed the relationship between MBI severity and cognition in community-dwelling older Latino adults. Methods: The cognitive function index (CFI) assessed subjective cognition, and the MBI-Checklist (MBI-C; self-report) measured MBI symptoms in 168 older Latinos (134 cognitively unimpaired, 34 with mild cognitive impairment). The Mini-Mental State Examination (MMSE) and NEUROPSI Delayed Word List Recall measured cognitive function. Linear regressions examined the impact of MBI-C symptoms on cognition, controlling for age, sex, and education. Results: The MBI domain of decreased motivation predicted subjective cognition and delayed verbal recall performance. The mood dysregulation domain predicted only subjective cognition. Neither domain predicted total MMSE scores. Discussion: MBI symptoms of decreased motivation and mood dysregulation influenced poorer subjective and objective cognition in Latinos, potentially signaling prodromal Alzheimer's related changes. These findings highlight the need to assess neuropsychiatric symptoms in this population. Highlights: Decreased motivation predicted worse subjective cognition and verbal memory. Mood dysregulation only predicted worse subjective cognition. These findings were adjusted for age, sex, and education in Latino older adults.
AB - Background: Mild behavioral impairment (MBI) is associated with cognitive decline and dementia risk. This study assessed the relationship between MBI severity and cognition in community-dwelling older Latino adults. Methods: The cognitive function index (CFI) assessed subjective cognition, and the MBI-Checklist (MBI-C; self-report) measured MBI symptoms in 168 older Latinos (134 cognitively unimpaired, 34 with mild cognitive impairment). The Mini-Mental State Examination (MMSE) and NEUROPSI Delayed Word List Recall measured cognitive function. Linear regressions examined the impact of MBI-C symptoms on cognition, controlling for age, sex, and education. Results: The MBI domain of decreased motivation predicted subjective cognition and delayed verbal recall performance. The mood dysregulation domain predicted only subjective cognition. Neither domain predicted total MMSE scores. Discussion: MBI symptoms of decreased motivation and mood dysregulation influenced poorer subjective and objective cognition in Latinos, potentially signaling prodromal Alzheimer's related changes. These findings highlight the need to assess neuropsychiatric symptoms in this population. Highlights: Decreased motivation predicted worse subjective cognition and verbal memory. Mood dysregulation only predicted worse subjective cognition. These findings were adjusted for age, sex, and education in Latino older adults.
KW - Alzheimer's disease and related dementias
KW - episodic verbal memory
KW - global cognition
KW - Latino/a/e/x
KW - mild behavioral impairment
KW - subjective cognitive decline
UR - https://www.scopus.com/pages/publications/105005263092
U2 - 10.1002/dad2.70121
DO - 10.1002/dad2.70121
M3 - Article
C2 - 42440956
AN - SCOPUS:105005263092
SN - 2352-8729
VL - 17
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
IS - 2
M1 - e70121
ER -