@article{93a8897ece6e4b448c15f6b1df59bb80,
title = "Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria",
abstract = "Blood platelets are critical for hemostasis and thrombosis and play diverse roles during immune responses. Despite these versatile tasks in mammalian biology, their skills on a cellular level are deemed limited, mainly consisting in rolling, adhesion, and aggregate formation. Here, we identify an unappreciated asset of platelets and show that adherent platelets use adhesion receptors to mechanically probe the adhesive substrate in their local microenvironment. When actomyosin-dependent traction forces overcome substrate resistance, platelets migrate and pile up the adhesive substrate together with any bound particulate material. They use this ability to act as cellular scavengers, scanning the vascular surface for potential invaders and collecting deposited bacteria. Microbe collection by migrating platelets boosts the activity of professional phagocytes, exacerbating inflammatory tissue injury in sepsis. This assigns platelets a central role in innate immune responses and identifies them as potential targets to dampen inflammatory tissue damage in clinical scenarios of severe systemic infection. In addition to their role in thrombosis and hemostasis, platelets can also migrate to sites of infection to help trap bacteria and clear the vascular surface.",
keywords = "NETosis, cell migration, host-defense, innate immunity, mechanosensing, methicillin-resistant S. aureus, neutrophils, platelets, polarization, sepsis",
author = "Florian Gaertner and Zerkah Ahmad and Gerhild Rosenberger and Shuxia Fan and Leo Nicolai and Benjamin Busch and G{\"o}kce Yavuz and Manja Luckner and Hellen Ishikawa-Ankerhold and Roman Hennel and Alexandre Benechet and Michael Lorenz and Sue Chandraratne and Irene Schubert and Sebastian Helmer and Bianca Striednig and Konstantin Stark and Marek Janko and B{\"o}ttcher, {Ralph T.} and Admar Verschoor and Catherine Leon and Christian Gachet and Thomas Gudermann and {Mederos y Schnitzler}, Michael and Zachary Pincus and Matteo Iannacone and Rainer Haas and Gerhard Wanner and Kirsten Lauber and Michael Sixt and Steffen Massberg",
note = "Funding Information: We thank Christin Lehmann, Anja Titova, Nicole Blount, and Cornelia Niemann for excellent technical assistance. We thank Reinhard F{\"a}ssler, Barbara Walzog, Eva Kiermaier, and Joachim Pilcher for helpful discussions. This study was supported by the DFG SFB 914 (S.M. [B02 and Z01], K.S. [B02], R.T.B. [A05], A.V. [B04], and R. Haas [B05]), the DFG SFB 1123 (S.M. [B06]), the DFG FOR 2033 (S.M. and F.G.), the German Centre for Cardiovascular Research (DZHK) (MHA 1.4VD [S.M.]), FP7 program (project 260309, PRESTIGE [S.M.]), F{\"o}FoLe project 947 (F.G.), the Friedrich-Baur-Stiftung project 41/16 (F.G.), Marie Sk{\l}odowska Curie Individual Fellowship (EU project 747687, LamelliActin [F.G.]). Funding Information: We thank Christin Lehmann, Anja Titova, Nicole Blount, and Cornelia Niemann for excellent technical assistance. We thank Reinhard F{\"a}ssler, Barbara Walzog, Eva Kiermaier, and Joachim Pilcher for helpful discussions. This study was supported by the DFG SFB 914 (S.M. [B02 and Z01], K.S. [B02], R.T.B. [A05], A.V. [B04], and R. Haas [B05]), the DFG SFB 1123 (S.M. [B06]), the DFG FOR 2033 (S.M. and F.G.), the German Centre for Cardiovascular Research (DZHK) ( MHA 1.4VD [S.M.]), FP7 program (project 260309, PRESTIGE [S.M.]), F{\"o}FoLe project 947 (F.G.), the Friedrich-Baur-Stiftung project 41/16 (F.G.), Marie Sk{\l}odowska Curie Individual Fellowship ( EU project 747687 , LamelliActin [F.G.]). Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",
year = "2017",
month = nov,
day = "30",
doi = "10.1016/j.cell.2017.11.001",
language = "English",
volume = "171",
pages = "1368--1382.e23",
journal = "Cell",
issn = "0092-8674",
number = "6",
}