TY - JOUR
T1 - Midbody
T2 - From cellular junk to regulator of cell polarity and cell fate
AU - Dionne, Lai Kuan
AU - Wang, Xiao Jing
AU - Prekeris, Rytis
N1 - Funding Information:
We apologize to our colleagues for not being able to cite all work related to cytokinesis due to the focused nature of this review and its requirement for brevity. We are grateful to Drs. Chad Pearson, Jeffrey Moore, and Kalen Dionne for their critical reading of this manuscript. Research in Dr. Rytis Prekeris’ laboratory is supported by the National Institute of Health ( R01 DK064380 ) and the Cancer League of Colorado Foundation . Research in Dr. Xiao-Jing Wang's laboratory is supported by the National Institute of Health ( R01 DE015953 and DE024371 ). Dr. Lai Kuan Dionne is supported by an NIH T32 training grant ( T32 CA174648 ) and Cancer League of Colorado Foundation .
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - At late mitosis, the mother cell divides by the formation of a cleavage furrow, leaving two daughter cells connected by a thin intercellular bridge. During ingression of the cleavage furrow, the central spindle microtubules are compacted to form the structure known as the midbody (MB). The MB is situated within the intercellular bridge, with the abscission site sometimes occurring on one side of the MB. As a result of this one-sided (asymmetric) abscission, only one daughter cell can inherit the post-mitotic MB. Interestingly, recent studies have identified post-mitotic MBs as novel signaling platforms regulating stem cell fate and proliferation. Additionally, MBs were proposed to serve a role of polarity cues during the neurite outgrowth and apical lumen formation. Thus, abscission and MB inheritance is clearly a highly regulated cellular event that can affect development and various other cellular functions. In this review we discuss the latest findings regarding post-mitotic MB functions, as well as the machinery regulating MB inheritance and accumulation.
AB - At late mitosis, the mother cell divides by the formation of a cleavage furrow, leaving two daughter cells connected by a thin intercellular bridge. During ingression of the cleavage furrow, the central spindle microtubules are compacted to form the structure known as the midbody (MB). The MB is situated within the intercellular bridge, with the abscission site sometimes occurring on one side of the MB. As a result of this one-sided (asymmetric) abscission, only one daughter cell can inherit the post-mitotic MB. Interestingly, recent studies have identified post-mitotic MBs as novel signaling platforms regulating stem cell fate and proliferation. Additionally, MBs were proposed to serve a role of polarity cues during the neurite outgrowth and apical lumen formation. Thus, abscission and MB inheritance is clearly a highly regulated cellular event that can affect development and various other cellular functions. In this review we discuss the latest findings regarding post-mitotic MB functions, as well as the machinery regulating MB inheritance and accumulation.
UR - http://www.scopus.com/inward/record.url?scp=84938710018&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2015.04.010
DO - 10.1016/j.ceb.2015.04.010
M3 - Review article
C2 - 25950842
AN - SCOPUS:84938710018
SN - 0955-0674
VL - 35
SP - 51
EP - 58
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
ER -