Microwave-assisted synthesis of di- and trisubstituted ureas from thiophenoxy carbamate resins

Blanca Martinez-Teipel, Rosalyn C. Green, Roland E. Dolle

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The microwave-assisted, parallel synthesis of di- and trisubstituted ureas is described. Microwave irradiation provides a significant rate enhancement to the in situ thermolytic cleavage of isocyanates from polymer-supported carbamates. The method is amenable to library production and the target ureas are generally obtained in good purities (> 80%).

Original languageEnglish
Pages (from-to)854-858
Number of pages5
JournalQSAR and Combinatorial Science
Volume23
Issue number10
DOIs
StatePublished - Dec 1 2004
Externally publishedYes

Keywords

  • Marshall resin
  • Microwave synthesis
  • Urea

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