Microwave-assisted efficient, one-pot, three-component synthesis of 3,5-disubstituted 1,2,4-oxadiazoles under solvent-free conditions

Mehdi Adib, Amin Haghighat Jahromi, Narjes Tavoosi, Mohammad Mahdavi, Hamid Reza Bijanzadeh

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

A novel synthesis of 1,2,4-oxadiazoles is described from a one-pot, three-component reaction between nitriles, hydroxylamine, and aldehydes under microwave irradiation and solvent-free conditions in excellent yields.

Original languageEnglish
Pages (from-to)2965-2967
Number of pages3
JournalTetrahedron Letters
Volume47
Issue number17
DOIs
StatePublished - Apr 24 2006

Keywords

  • 1,2,4-Oxadiazoles
  • Aldehydes
  • Microwave irradiation
  • One-pot, three-component reaction
  • Solvent-free synthesis

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