Microvesicle-associated tissue factor and Trousseau's syndrome

I. Del Conde, L. D. Bharwani, D. J. Dietzen, U. Pendurthi, P. Thiagarajan, José A. López

Research output: Contribution to journalArticle

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Abstract

Background: Trousseau's syndrome is a prothrombotic state associated with malignancy that is poorly understood pathophysiologically. Methodsand Results: Here we report studies on the blood of a 55-year-old man with giant-cell lung carcinoma who developed a severe form of Trousseau's syndrome. His clinical course was dominated by an extremely hypercoagulable state. Despite receiving potent antithrombotic therapy, he suffered eleven major arterial and venous thrombotic events over a 5 month period. We examined the patient's blood for tissue factor (TF), the major initiator of coagulation, and found its concentration in his plasma to be forty-one-fold higher than the mean concentration derived from testing of 16 normal individuals. Conclusion: Almost all of the TFin the patient's plasma was associated with cell-derived microvesicles, likely shed by the cancer cells.

Original languageEnglish
Pages (from-to)70-74
Number of pages5
JournalJournal of Thrombosis and Haemostasis
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2007

Keywords

  • Cancer
  • Microvesicles
  • Thrombosis
  • Tissue factor
  • Trousseau's syndrome

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