Microvascular platelet aggregation and thrombosis after subarachnoid hemorrhage: A review and synthesis

Julian V. Clarke, Julia M. Suggs, Deepti Diwan, Jin V. Lee, Kim Lipsey, Ananth K. Vellimana, Gregory J. Zipfel

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH) has been associated with numerous pathophysiological sequelae, including large artery vasospasm and microvascular thrombosis. The focus of this review is to provide an overview of experimental animal model studies and human autopsy studies that explore the temporal-spatial characterization and mechanism of microvascular platelet aggregation and thrombosis following SAH, as well as to critically assess experimental studies and clinical trials highlighting preventative therapeutic options against this highly morbid pathophysiological process. Upon review of the literature, we discovered that microvascular platelet aggregation and thrombosis occur after experimental SAH across multiple species and SAH induction techniques in a similar time frame to other components of DCI, occurring in the cerebral cortex and hippocampus across both hemispheres. We discuss the relationship of these findings to human autopsy studies. In the final section of this review, we highlight the important therapeutic options for targeting microvascular platelet aggregation and thrombosis, and emphasize why therapeutic targeting of this neurovascular pathology may improve patient care. We encourage ongoing research into the pathophysiology of SAH and DCI, especially in regard to microvascular platelet aggregation and thrombosis and the translation to randomized clinical trials.

Original languageEnglish
Pages (from-to)1565-1575
Number of pages11
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number8
StatePublished - Aug 1 2020


  • Microcirculation
  • animal models
  • animal studies
  • brain ischemia
  • cerebrovascular disease
  • subarachnoid hemorrhage
  • vasospasm


Dive into the research topics of 'Microvascular platelet aggregation and thrombosis after subarachnoid hemorrhage: A review and synthesis'. Together they form a unique fingerprint.

Cite this