Abstract
One of the simplest molecular motors, a biological microtubule, is reviewed as an example of a highly nonequili- brium molecular machine capable of stochastic transitions be- tween slow growth and rapid disassembly phases. Basic properties of microtubules are described, and various ap- proaches to simulating their dynamics, from statistical chemi- cal kinetics models to molecular dynamics models using the Metropolis Monte Carlo and Brownian dynamics methods, are outlined.
Original language | English |
---|---|
Pages (from-to) | 773-786 |
Number of pages | 14 |
Journal | Physics-Uspekhi |
Volume | 59 |
Issue number | 8 |
DOIs | |
State | Published - 2016 |
Keywords
- Dynamic instability
- GTP cap
- Mathematical modeling
- Microtubule