Microtubules: Dynamically unstable stochastic phase-switching polymers

P. N. Zakharov, V. K. Arzhanik, E. V. Ulyanov, N. B. Gudimchuk, F. I. Ataullakhanov

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

One of the simplest molecular motors, a biological microtubule, is reviewed as an example of a highly nonequili- brium molecular machine capable of stochastic transitions be- tween slow growth and rapid disassembly phases. Basic properties of microtubules are described, and various ap- proaches to simulating their dynamics, from statistical chemi- cal kinetics models to molecular dynamics models using the Metropolis Monte Carlo and Brownian dynamics methods, are outlined.

Original languageEnglish
Pages (from-to)773-786
Number of pages14
JournalPhysics-Uspekhi
Volume59
Issue number8
DOIs
StatePublished - 2016

Keywords

  • Dynamic instability
  • GTP cap
  • Mathematical modeling
  • Microtubule

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