Microstructural maturation of white matter tracts in encephalopathic neonates

Akash P. Kansagra; Marc C. Mabray; Donna M. Ferriero; A. James Barkovich; Duan Xu; Christopher P. Hess

doi:10.1016/j.clinimag.2016.05.009

Microstructural maturation of white matter tracts in encephalopathic neonates

Akash P. Kansagra, Marc C. Mabray, Donna M. Ferriero, A. James Barkovich, Duan Xu, Christopher P. Hess

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Purpose: This study aims to apply neurite orientation dispersion and density imaging (NODDI) to measure white matter microstructural features during early development. Methods: NODDI parameters were measured in twelve newborns and thirteen 6-month infants, all with perinatal clinical encephalopathy. Results: Between 0 and 6 months, there were significant differences in fractional anisotropy (FA) for all tracts; in neurite density for internal capsules, optic radiations, and splenium; and in orientation dispersion for anterior limb of internal capsule and optic radiations. There were no appreciable differences in NODDI parameters related to outcome. Conclusion: NODDI may allow more detailed characterization of microstructural maturation than FA.

Original language	English
Pages (from-to)	1009-1013
Number of pages	5
Journal	Clinical Imaging
Volume	40
Issue number	5
DOIs	https://doi.org/10.1016/j.clinimag.2016.05.009
State	Published - Sep 1 2016

Keywords

Brain
Diffusion tensor imaging
Magnetic resonance imaging
Maturation
Microstructure
Pediatrics

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10.1016/j.clinimag.2016.05.009

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title = "Microstructural maturation of white matter tracts in encephalopathic neonates",

abstract = "Purpose: This study aims to apply neurite orientation dispersion and density imaging (NODDI) to measure white matter microstructural features during early development. Methods: NODDI parameters were measured in twelve newborns and thirteen 6-month infants, all with perinatal clinical encephalopathy. Results: Between 0 and 6 months, there were significant differences in fractional anisotropy (FA) for all tracts; in neurite density for internal capsules, optic radiations, and splenium; and in orientation dispersion for anterior limb of internal capsule and optic radiations. There were no appreciable differences in NODDI parameters related to outcome. Conclusion: NODDI may allow more detailed characterization of microstructural maturation than FA.",

keywords = "Brain, Diffusion tensor imaging, Magnetic resonance imaging, Maturation, Microstructure, Pediatrics",

author = "Kansagra, {Akash P.} and Mabray, {Marc C.} and Ferriero, {Donna M.} and Barkovich, {A. James} and Duan Xu and Hess, {Christopher P.}",

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doi = "10.1016/j.clinimag.2016.05.009",

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T1 - Microstructural maturation of white matter tracts in encephalopathic neonates

AU - Kansagra, Akash P.

AU - Mabray, Marc C.

AU - Ferriero, Donna M.

AU - Barkovich, A. James

AU - Xu, Duan

AU - Hess, Christopher P.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Purpose: This study aims to apply neurite orientation dispersion and density imaging (NODDI) to measure white matter microstructural features during early development. Methods: NODDI parameters were measured in twelve newborns and thirteen 6-month infants, all with perinatal clinical encephalopathy. Results: Between 0 and 6 months, there were significant differences in fractional anisotropy (FA) for all tracts; in neurite density for internal capsules, optic radiations, and splenium; and in orientation dispersion for anterior limb of internal capsule and optic radiations. There were no appreciable differences in NODDI parameters related to outcome. Conclusion: NODDI may allow more detailed characterization of microstructural maturation than FA.

AB - Purpose: This study aims to apply neurite orientation dispersion and density imaging (NODDI) to measure white matter microstructural features during early development. Methods: NODDI parameters were measured in twelve newborns and thirteen 6-month infants, all with perinatal clinical encephalopathy. Results: Between 0 and 6 months, there were significant differences in fractional anisotropy (FA) for all tracts; in neurite density for internal capsules, optic radiations, and splenium; and in orientation dispersion for anterior limb of internal capsule and optic radiations. There were no appreciable differences in NODDI parameters related to outcome. Conclusion: NODDI may allow more detailed characterization of microstructural maturation than FA.

KW - Brain

KW - Diffusion tensor imaging

KW - Magnetic resonance imaging

KW - Maturation

KW - Microstructure

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Microstructural maturation of white matter tracts in encephalopathic neonates

Abstract

Keywords

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