MicroRNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity

Michael Hollis; Kavitha Nair; Arpita Vyas; Lakshmi Shankar Chaturvedi; Sahil Gambhir; Dinesh Vyas

doi:10.3748/wjg.v21.i27.8284

MicroRNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity

Michael Hollis, Kavitha Nair, Arpita Vyas, Lakshmi Shankar Chaturvedi, Sahil Gambhir, Dinesh Vyas

Division of Endocrinology and Diabetes

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115 Scopus citations

Abstract

Over the past decade, research has shown that aberrant expression of microRNA (miRNA) is involved in colorectal cancer development and progression. MicroRNAs are small sequences of non-coding RNA that regulate expression of genes involved in important cellular functions, such as cell differentiation, multiplication, and apoptosis. A specific miRNA may display the effects of a tumor suppressor or oncogene. Altered miRNA expression is found in colorectal cancer (CRC) and patterns of miRNA expression correlate with CRC detection and outcome. Studies also have examined the use of circulating serum miRNA and fecal miRNA expression as non-invasive markers for early detection. Here, we review recent evidence demonstrating the potential role of miRNA in CRC and the implications of its use in the diagnosis, prognosis, and management of CRC.

Original language	English
Pages (from-to)	8284-8292
Number of pages	9
Journal	World Journal of Gastroenterology
Volume	21
Issue number	27
DOIs	https://doi.org/10.3748/wjg.v21.i27.8284
State	Published - Jul 21 2015

Keywords

Colorectal cancer
Diagnostic
Expression
Fecal microRNA
Microrna
Prognostic
Serum microRNA
Therapeutic

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10.3748/wjg.v21.i27.8284

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title = "MicroRNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity",

abstract = "Over the past decade, research has shown that aberrant expression of microRNA (miRNA) is involved in colorectal cancer development and progression. MicroRNAs are small sequences of non-coding RNA that regulate expression of genes involved in important cellular functions, such as cell differentiation, multiplication, and apoptosis. A specific miRNA may display the effects of a tumor suppressor or oncogene. Altered miRNA expression is found in colorectal cancer (CRC) and patterns of miRNA expression correlate with CRC detection and outcome. Studies also have examined the use of circulating serum miRNA and fecal miRNA expression as non-invasive markers for early detection. Here, we review recent evidence demonstrating the potential role of miRNA in CRC and the implications of its use in the diagnosis, prognosis, and management of CRC.",

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AU - Nair, Kavitha

AU - Vyas, Arpita

AU - Chaturvedi, Lakshmi Shankar

AU - Gambhir, Sahil

AU - Vyas, Dinesh

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AB - Over the past decade, research has shown that aberrant expression of microRNA (miRNA) is involved in colorectal cancer development and progression. MicroRNAs are small sequences of non-coding RNA that regulate expression of genes involved in important cellular functions, such as cell differentiation, multiplication, and apoptosis. A specific miRNA may display the effects of a tumor suppressor or oncogene. Altered miRNA expression is found in colorectal cancer (CRC) and patterns of miRNA expression correlate with CRC detection and outcome. Studies also have examined the use of circulating serum miRNA and fecal miRNA expression as non-invasive markers for early detection. Here, we review recent evidence demonstrating the potential role of miRNA in CRC and the implications of its use in the diagnosis, prognosis, and management of CRC.

KW - Colorectal cancer

KW - Diagnostic

KW - Expression

KW - Fecal microRNA

KW - Microrna

KW - Prognostic

KW - Serum microRNA

KW - Therapeutic

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MicroRNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity

Abstract

Keywords

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