TY - JOUR
T1 - MicroRNAs, an active and versatile group in cancers
AU - Liu, Jeffrey
AU - Zheng, Min
AU - Tang, Yaling
AU - Liang, Xinhua
AU - Yang, Qin
PY - 2011/10
Y1 - 2011/10
N2 - microRNAs (miRNAs) are a class of noncoding RNAs that function as endogenous triggers of the RNA interference pathway. Studies have shown that thousands of human proteincoding genes are regulated by miRNAs, indicating that miRNAs are master regulators of many important biological processes, such as cancer development. miRNAs frequently have deregulated expression in many types of human cancers, and play critical roles in tumorigenesis, which functions either as tumor suppressors or as oncogenes. Recent studies have shown that miRNAs are highly related with cancer progression, including initiating, growth, apoptosis, invasion, and metastasis. Furthermore, miRNAs are shown to be responsible for the cancerrelated inflammation, anticancer drug resistance, and regulation of cancer stem cells. Therefore, miRNAs have generated great interest as a novel strategy in cancer diagnosis and therapy. Here we review the versatile roles of miRNAs in cancers and their potential applications for diagnosis, prognosis, and treatment as biomarkers.
AB - microRNAs (miRNAs) are a class of noncoding RNAs that function as endogenous triggers of the RNA interference pathway. Studies have shown that thousands of human proteincoding genes are regulated by miRNAs, indicating that miRNAs are master regulators of many important biological processes, such as cancer development. miRNAs frequently have deregulated expression in many types of human cancers, and play critical roles in tumorigenesis, which functions either as tumor suppressors or as oncogenes. Recent studies have shown that miRNAs are highly related with cancer progression, including initiating, growth, apoptosis, invasion, and metastasis. Furthermore, miRNAs are shown to be responsible for the cancerrelated inflammation, anticancer drug resistance, and regulation of cancer stem cells. Therefore, miRNAs have generated great interest as a novel strategy in cancer diagnosis and therapy. Here we review the versatile roles of miRNAs in cancers and their potential applications for diagnosis, prognosis, and treatment as biomarkers.
KW - cancer
KW - cancer stem cells
KW - drug resistance
KW - epithelial-mesenchymal transition
KW - inflammation
KW - microRNAs
UR - http://www.scopus.com/inward/record.url?scp=80055092259&partnerID=8YFLogxK
U2 - 10.4248/IJOS11063
DO - 10.4248/IJOS11063
M3 - Review article
C2 - 22010574
AN - SCOPUS:80055092259
VL - 3
SP - 165
EP - 175
JO - International Journal of Oral Science
JF - International Journal of Oral Science
SN - 1674-2818
IS - 4
ER -