MicroRNA-dependent genetic networks during neural development

Daniel G. Abernathy, Andrew S. Yoo

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

The development of the structurally and functionally diverse mammalian nervous system requires the integration of numerous levels of gene regulation. Accumulating evidence suggests that microRNAs are key mediators of genetic networks during neural development. Importantly, microRNAs are found to regulate both feedback and feedforward loops during neural development leading to large changes in gene expression. These repressive interactions provide an additional mechanism that facilitates the establishment of complexity within the nervous system. Here, we review studies that have enabled the identification of microRNAs enriched in the brain and discuss the way that genetic networks in neural development depend on microRNAs.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalCell and Tissue Research
Volume359
Issue number1
DOIs
StatePublished - Jan 2015

Keywords

  • Brain
  • Direct reprogramming
  • Epigenetics
  • Genetic networks
  • MicroRNAs
  • Neural development

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