MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of alzheimer disease subjects

Justin M. Long; Balmiki Ray; Debomoy K. Lahiri

doi:10.1074/jbc.M113.518241

MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of alzheimer disease subjects

Justin M. Long
, Balmiki Ray
, Debomoy K. Lahiri

Research output: Contribution to journal › Article › peer-review

172 Scopus citations

Abstract

Background: BACE1 is the rate-limiting enzyme in the synthesis of Aβ from amyloid precursor protein. Results: Human miR-339-5p negatively regulates BACE1 and Aβ in human brain cultures and is reduced in AD specimens. Conclusion: Human miR-339-5p physiologically regulates human BACE1 protein expression and Aβ and is dysregulated in the AD brain. Significance: miR-339-5p represents a novel drug target in AD.

Original language	English
Pages (from-to)	5184-5198
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	289
Issue number	8
DOIs	https://doi.org/10.1074/jbc.M113.518241
State	Published - Feb 21 2014

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title = "MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of alzheimer disease subjects",

abstract = "Background: BACE1 is the rate-limiting enzyme in the synthesis of Aβ from amyloid precursor protein. Results: Human miR-339-5p negatively regulates BACE1 and Aβ in human brain cultures and is reduced in AD specimens. Conclusion: Human miR-339-5p physiologically regulates human BACE1 protein expression and Aβ and is dysregulated in the AD brain. Significance: miR-339-5p represents a novel drug target in AD.",

author = "Long, \{Justin M.\} and Balmiki Ray and Lahiri, \{Debomoy K.\}",

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MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of alzheimer disease subjects. / Long, Justin M.; Ray, Balmiki; Lahiri, Debomoy K.
In: Journal of Biological Chemistry, Vol. 289, No. 8, 21.02.2014, p. 5184-5198.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

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AU - Long, Justin M.

AU - Ray, Balmiki

AU - Lahiri, Debomoy K.

PY - 2014/2/21

Y1 - 2014/2/21

N2 - Background: BACE1 is the rate-limiting enzyme in the synthesis of Aβ from amyloid precursor protein. Results: Human miR-339-5p negatively regulates BACE1 and Aβ in human brain cultures and is reduced in AD specimens. Conclusion: Human miR-339-5p physiologically regulates human BACE1 protein expression and Aβ and is dysregulated in the AD brain. Significance: miR-339-5p represents a novel drug target in AD.

AB - Background: BACE1 is the rate-limiting enzyme in the synthesis of Aβ from amyloid precursor protein. Results: Human miR-339-5p negatively regulates BACE1 and Aβ in human brain cultures and is reduced in AD specimens. Conclusion: Human miR-339-5p physiologically regulates human BACE1 protein expression and Aβ and is dysregulated in the AD brain. Significance: miR-339-5p represents a novel drug target in AD.

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DO - 10.1074/jbc.M113.518241

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MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of alzheimer disease subjects

Abstract

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