Microreactors for click chemistry-based synthesis of molecular imaging probes

J. J. Whittenberg, H. Li, H. Zhou, J. Koziol, A. V. Desai, D. E. Reichert, P. J.A. Kenis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have developed a microreactor with immobilized Cu(I) catalyst on the surfaces to use for Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. The presence of immobilized Cu(I) was confirmed visually with bright-field microscopy and also with X-ray photoelectron spectroscopy (XPS). Cu(I) immobilized reactors were validated with reactions between simple alkynes and azides to confirm the efficacy of the Cu(I) catalyst. The microreactors were then utilized to synthesize a molecular imaging probe precursor.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages2363-2365
Number of pages3
ISBN (Electronic)9780979806476
StatePublished - Jan 1 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: Oct 26 2014Oct 30 2014

Publication series

Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Conference

Conference18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period10/26/1410/30/14

Keywords

  • Catalyst immobilization
  • Click chemistry
  • Microfluidics
  • Molecular imaging probes

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  • Cite this

    Whittenberg, J. J., Li, H., Zhou, H., Koziol, J., Desai, A. V., Reichert, D. E., & Kenis, P. J. A. (2014). Microreactors for click chemistry-based synthesis of molecular imaging probes. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 2363-2365). (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014). Chemical and Biological Microsystems Society.