Microglial/macrophage GRK2 determines duration of peripheral IL-1β-induced hyperalgesia: Contribution of spinal cord CX3CR1, p38 and IL-1 signaling

Keyphrases

• Interleukin-1β 100%
• Microglia 100%
• Macrophages 100%
• Spinal Cord 100%
• CX3CR1 100%
• Interleukin-1 Signaling 100%
• Hyperalgesia 100%
• GRK2 100%
• Macrophage Activity 25%
• Chronic Inflammation 16%
• LysM 16%
• Granulocytes 16%
• Minocycline 16%
• Fractalkine 16%
• Interleukin-1 Receptor Antagonist (IL-1Ra) 8%
• Inflammatory Cytokines 8%
• Inflammation 8%
• Gene-deficient Mice 8%
• Astrocytes 8%
• Chronic Inflammatory Diseases 8%
• Genotype 8%
• Lumbar 8%
• Intrathecal 8%
• Macrophage Activation 8%
• Clinical Problems 8%
• Chronic Pain 8%
• Sensory Neurons 8%
• Intrathecal Administration 8%
• Cre-loxP 8%
• MAPK Inhibitors 8%
• Thoracic Spinal Cord 8%
• Inflammatory Hyperalgesia 8%
• Spinal Microglia 8%
• P38 Activation 8%
• Interleukin-1 Antagonist 8%
• SB239063 8%

Neuroscience

• Macrophage 100%
• Interleukin 1 100%
• Hyperalgesia 100%
• CX3CR1 100%
• Microglia 41%
• Intrathecal 16%
• Fractalkine 16%
• Minocycline 16%
• Polymorphonuclear Cell 16%
• Astrocyte 8%
• Sensory Neuron 8%
• Proinflammatory Cytokine 8%
• 4 [4 (4 Fluorophenyl) 5 (2 Methoxy 4 Pyrimidinyl) 1 Imidazolyl]cyclohexanol 8%

Medicine and Dentistry

• Interleukin 1 100%
• Macrophage 100%
• Hyperpathia 100%
• Microglia 41%
• Chronic Inflammation 16%
• Granulocyte 16%
• Minocycline 16%
• Fractalkine 16%
• Intraplantar Drug Administration 16%
• Interleukin 1 Receptor Blocking Agent 8%
• Inflammatory Cytokine 8%
• Astrocyte 8%
• Chronic Pain 8%
• Macrophage Activation 8%
• Intrathecal Drug Administration 8%
• Thoracic Spinal Cord 8%
• 4 [4 (4 Fluorophenyl) 5 (2 Methoxy 4 Pyrimidinyl) 1 Imidazolyl]cyclohexanol 8%