Abstract
Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on disease. We show in mice that microglial microRNA expression differs in males and females and that loss of microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology. These findings suggest that microglial microRNAs influence tau pathogenesis in a sex-specific manner.
Original language | English |
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Pages (from-to) | 167-171 |
Number of pages | 5 |
Journal | Nature neuroscience |
Volume | 23 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2020 |