@article{48211cbc642a410cac3e097cd6ff9a23,
title = "Microglial microRNAs mediate sex-specific responses to tau pathology",
abstract = "Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on disease. We show in mice that microglial microRNA expression differs in males and females and that loss of microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology. These findings suggest that microglial microRNAs influence tau pathogenesis in a sex-specific manner.",
author = "Lay Kodama and Elmer Guzman and Etchegaray, {Jon I.} and Yaqiao Li and Sayed, {Faten A.} and Lu Zhou and Yungui Zhou and Lihong Zhan and David Le and Udeochu, {Joe C.} and Clelland, {Claire D.} and Zuolin Cheng and Guoqiang Yu and Qingyun Li and Kosik, {Kenneth S.} and Li Gan",
note = "Funding Information: We thank the Gladstone Histology and Light Microscopy Core and the Weill Cornell Medicine CLC Microscopy and Image Analysis Core Facility for help with imaging, and the Gladstone Bioinformatics Core for help with the analysis of sequencing. Bulk RNA-seq was carried out at the Center for Advanced Technology, University of California, San Francisco. scRNA-seq was carried out at the Weill Cornell Medicine Genomics and Epigenomics Core Facility. FACS was carried out at the Stanford FACS Facility. We thank S. Ordway and K. Claiborn for editing the manuscript, K. M. Ansel and his laboratory members for comments on the manuscript and discussions on miRNA biology, and Y. Fu for the DicerloxP/loxP mice. This work was supported by National Institutes of Health (NIH) grant nos. 1R01AG054214-01A1, U54NS100717, R01AG051390 and a Tau Consortium grant to L.G.; NIH grant nos. 1F30AG062043-02 and T32GM007618 to L.K.; NIH grant no. F31AG058505 to F.A.S.; NIH grant no. U54NS100717, Dr. Miriam and Sheldon G. Adelson Medical Research Foundation grant no. SB180058, Larry L. Hillblom Foundation grant no. 2018-A-0004-NET, and the Edward N. and Della L. Thome Memorial Foundation grant no. SB180126 to K.S.K.; Alzheimer{\textquoteright}s Association AACSF grant no. 17-531484, NIH grant no. R25 R25NS070680 and UCSF Clinical and Translational Science Institute grant no. 5TL1TR0018 to C.D.C.; IRACDA Postdoctoral fellowship grant no. K12GM081266-11 to J.C.U.; and grant no. R01MH110504 to G.Y. Gladstone Institutes received support from the National Center for Research Resources grant no. RR18928. Publisher Copyright: {\textcopyright} 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2020",
month = feb,
day = "1",
doi = "10.1038/s41593-019-0560-7",
language = "English",
volume = "23",
pages = "167--171",
journal = "Nature neuroscience",
issn = "1097-6256",
number = "2",
}