Microglial microRNAs mediate sex-specific responses to tau pathology

Lay Kodama, Elmer Guzman, Jon I. Etchegaray, Yaqiao Li, Faten A. Sayed, Lu Zhou, Yungui Zhou, Lihong Zhan, David Le, Joe C. Udeochu, Claire D. Clelland, Zuolin Cheng, Guoqiang Yu, Qingyun Li, Kenneth S. Kosik, Li Gan

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on disease. We show in mice that microglial microRNA expression differs in males and females and that loss of microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology. These findings suggest that microglial microRNAs influence tau pathogenesis in a sex-specific manner.

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalNature neuroscience
Issue number2
StatePublished - Feb 1 2020


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