TY - JOUR
T1 - Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology
AU - Gutmann, David H.
AU - Kettenmann, Helmut
N1 - Funding Information:
We appreciate the support from a Berlin Institute of Health/Einstein fellowship grant to D.H.G. and H.K., an Alexander von Humboldt Foundation grant to D.H.G., and the Helmholtz-Gemeinschaft, Zukunftsthema “Immunology and Inflammation” grant to H.K. ( ZT-0027 ).
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/11/6
Y1 - 2019/11/6
N2 - One of the most common brain tumors in children and adults is glioma or astrocytoma. There are few effective therapies for these cancers, and patients with malignant glioma fare poorly, even after aggressive surgery, chemotherapy, and radiation. Over the past decade, it is now appreciated that these tumors are composed of numerous distinct neoplastic and non-neoplastic cell populations, which could each influence overall tumor biology and response to therapy. Among these noncancerous cell types, monocytes (microglia and macrophages) predominate. In this Review, we discuss the complex interactions involving microglia and macrophages relevant to glioma formation, progression, and response to therapy. Like other cancers, brain tumors (gliomas) are composed of many different cell types, including non-neoplastic monocytic cells (macrophages and microglia). In this Review, Gutmann and Kettenmann discuss the importance of these cells to glioma development, maintenance, and treatment response.
AB - One of the most common brain tumors in children and adults is glioma or astrocytoma. There are few effective therapies for these cancers, and patients with malignant glioma fare poorly, even after aggressive surgery, chemotherapy, and radiation. Over the past decade, it is now appreciated that these tumors are composed of numerous distinct neoplastic and non-neoplastic cell populations, which could each influence overall tumor biology and response to therapy. Among these noncancerous cell types, monocytes (microglia and macrophages) predominate. In this Review, we discuss the complex interactions involving microglia and macrophages relevant to glioma formation, progression, and response to therapy. Like other cancers, brain tumors (gliomas) are composed of many different cell types, including non-neoplastic monocytic cells (macrophages and microglia). In this Review, Gutmann and Kettenmann discuss the importance of these cells to glioma development, maintenance, and treatment response.
KW - glioblastoma
KW - glioma
KW - immune
KW - macrophages
KW - microglia
KW - monocyte
UR - http://www.scopus.com/inward/record.url?scp=85074309089&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2019.08.028
DO - 10.1016/j.neuron.2019.08.028
M3 - Review article
C2 - 31697921
AN - SCOPUS:85074309089
SN - 0896-6273
VL - 104
SP - 442
EP - 449
JO - Neuron
JF - Neuron
IS - 3
ER -