Microglia replacement: from monocytic origin to therapy

Jingyi Yang; Qingyun Li

doi:10.1016/j.it.2025.05.001

Microglia replacement: from monocytic origin to therapy

Jingyi Yang
, Qingyun Li

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Microglia replacement is reshaping neurodegenerative disease therapy, yet its key prerequisites remain unclear. In the current issue of Immunity, Aisenberg et al. and Bastos et al. reveal how developmental origin influences monocyte engraftment into the brain, and demonstrate the therapeutic potential of monocyte-based interventions in a monogenic neurological disease.

Original language	English
Pages (from-to)	429-431
Number of pages	3
Journal	Trends in Immunology
Volume	46
Issue number	6
DOIs	https://doi.org/10.1016/j.it.2025.05.001
State	Published - Jun 2025

Keywords

Krabbe disease
border-associated macrophage
brain immunology
disease-associated macrophage
globoid cell leukodystrophy
hematopoietic stem cell transplant
microglia
microglia replacement
ontogeny

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10.1016/j.it.2025.05.001

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title = "Microglia replacement: from monocytic origin to therapy",

abstract = "Microglia replacement is reshaping neurodegenerative disease therapy, yet its key prerequisites remain unclear. In the current issue of Immunity, Aisenberg et al. and Bastos et al. reveal how developmental origin influences monocyte engraftment into the brain, and demonstrate the therapeutic potential of monocyte-based interventions in a monogenic neurological disease.",

keywords = "Krabbe disease, border-associated macrophage, brain immunology, disease-associated macrophage, globoid cell leukodystrophy, hematopoietic stem cell transplant, microglia, microglia replacement, ontogeny",

author = "Jingyi Yang and Qingyun Li",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Ltd",

year = "2025",

month = jun,

doi = "10.1016/j.it.2025.05.001",

language = "English",

volume = "46",

pages = "429--431",

journal = "Trends in Immunology",

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TY - JOUR

T1 - Microglia replacement

T2 - from monocytic origin to therapy

AU - Yang, Jingyi

AU - Li, Qingyun

PY - 2025/6

Y1 - 2025/6

N2 - Microglia replacement is reshaping neurodegenerative disease therapy, yet its key prerequisites remain unclear. In the current issue of Immunity, Aisenberg et al. and Bastos et al. reveal how developmental origin influences monocyte engraftment into the brain, and demonstrate the therapeutic potential of monocyte-based interventions in a monogenic neurological disease.

AB - Microglia replacement is reshaping neurodegenerative disease therapy, yet its key prerequisites remain unclear. In the current issue of Immunity, Aisenberg et al. and Bastos et al. reveal how developmental origin influences monocyte engraftment into the brain, and demonstrate the therapeutic potential of monocyte-based interventions in a monogenic neurological disease.

KW - Krabbe disease

KW - border-associated macrophage

KW - brain immunology

KW - disease-associated macrophage

KW - globoid cell leukodystrophy

KW - hematopoietic stem cell transplant

KW - microglia

KW - microglia replacement

KW - ontogeny

UR - https://www.scopus.com/pages/publications/105006755478

U2 - 10.1016/j.it.2025.05.001

DO - 10.1016/j.it.2025.05.001

M3 - Short survey

C2 - 40425373

AN - SCOPUS:105006755478

SN - 1471-4906

VL - 46

SP - 429

EP - 431

JO - Trends in Immunology

JF - Trends in Immunology

IS - 6

ER -

Microglia replacement: from monocytic origin to therapy

Abstract

Keywords

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