Microglia in Alzheimer's disease: A target for immunotherapy

Shoutang Wang, Marco Colonna

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Microglia are resident Mϕs of the CNS that play pleiotropic functions in brain development and homeostasis. Impaired microglial functions are thought to be involved in the onset and progression of various neurodevelopmental and neurodegenerative diseases. Thus, understanding microglia in these settings may indicate new approaches for therapeutic intervention. Here, we review recent evidence implicating microglia in Alzheimer's disease and discuss potential therapeutic strategies targeting microglia and their receptors in this disease.

Original languageEnglish
Pages (from-to)219-227
Number of pages9
JournalJournal of Leukocyte Biology
Volume106
Issue number1
DOIs
StatePublished - Jul 2019

Keywords

  • Alzheimer's disease
  • TREM2
  • immunotherapy
  • microglia
  • neuroinflammation
  • phagocytosis

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