Microglia esprit de corps: Sharing the burden of eliminating toxic aggregates

Yun Chen; Marco Colonna

doi:10.1016/j.cell.2021.08.033

Microglia esprit de corps: Sharing the burden of eliminating toxic aggregates

Yun Chen, Marco Colonna

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Microglia play critical roles in the defense against neurodegenerative diseases. In this issue of Cell, Scheiblich et al. focus on microglia that ingest toxic aggregates of α-synuclein, finding that α-synuclein-replete microglia exchange aggregates for healthy mitochondria via nanotube connections to unaffected microglia. This communication enables a shared approach to aggregates disposal while preserving the health of the microglial population.

Original language	English
Pages (from-to)	5082-5084
Number of pages	3
Journal	Cell
Volume	184
Issue number	20
DOIs	https://doi.org/10.1016/j.cell.2021.08.033
State	Published - Sep 30 2021

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title = "Microglia esprit de corps: Sharing the burden of eliminating toxic aggregates",

abstract = "Microglia play critical roles in the defense against neurodegenerative diseases. In this issue of Cell, Scheiblich et al. focus on microglia that ingest toxic aggregates of α-synuclein, finding that α-synuclein-replete microglia exchange aggregates for healthy mitochondria via nanotube connections to unaffected microglia. This communication enables a shared approach to aggregates disposal while preserving the health of the microglial population.",

author = "Yun Chen and Marco Colonna",

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AB - Microglia play critical roles in the defense against neurodegenerative diseases. In this issue of Cell, Scheiblich et al. focus on microglia that ingest toxic aggregates of α-synuclein, finding that α-synuclein-replete microglia exchange aggregates for healthy mitochondria via nanotube connections to unaffected microglia. This communication enables a shared approach to aggregates disposal while preserving the health of the microglial population.

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Microglia esprit de corps: Sharing the burden of eliminating toxic aggregates

Abstract

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