TY - JOUR
T1 - Microglia as Dynamic Cellular Mediators of Brain Function
AU - Wright-Jin, Elizabeth C.
AU - Gutmann, David H.
N1 - Funding Information:
We appreciate the comments and discussions provided by Drs Michelle Monje (Stanford University) and Shane Liddelow (New York University), as well as by members of our laboratory, during the writing of this review. D.H.G. is the recipient of a National Institute of Neurological Disorders and Stroke (NINDS) R35 RPA grant (1-R35-NS07211-01).
Funding Information:
We appreciate the comments and discussions provided by Drs Michelle Monje (Stanford University) and Shane Liddelow (New York University), as well as by members of our laboratory, during the writing of this review. D.H.G. is the recipient of a National Institute of Neurological Disorders and Stroke (NINDS) R35 RPA grant (1-R35-NS07211-01).
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/11
Y1 - 2019/11
N2 - Originally hypothesized to function solely as immunologic responders within the central nervous system (CNS), emerging evidence has revealed that microglia have more complex roles in normal brain development and in the context of disease. In health, microglia influence neural progenitor fate decisions, astrocyte activation, neuronal homeostasis, and synaptogenesis. In the setting of brain disease, including autism, brain tumors, and neurodegenerative disorders, microglia undergo substantial morphological, molecular, and functional changes, which establish new biological states relevant to disease pathogenesis and progression. In this review, we discuss the function of microglia in health and disease and outline a conceptual framework for elucidating their specific contributions to nervous system pathobiology.
AB - Originally hypothesized to function solely as immunologic responders within the central nervous system (CNS), emerging evidence has revealed that microglia have more complex roles in normal brain development and in the context of disease. In health, microglia influence neural progenitor fate decisions, astrocyte activation, neuronal homeostasis, and synaptogenesis. In the setting of brain disease, including autism, brain tumors, and neurodegenerative disorders, microglia undergo substantial morphological, molecular, and functional changes, which establish new biological states relevant to disease pathogenesis and progression. In this review, we discuss the function of microglia in health and disease and outline a conceptual framework for elucidating their specific contributions to nervous system pathobiology.
KW - brain
KW - central nervous system
KW - glioma
KW - macrophage
KW - microglia
KW - precision medicine
UR - http://www.scopus.com/inward/record.url?scp=85073032144&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2019.08.013
DO - 10.1016/j.molmed.2019.08.013
M3 - Review article
C2 - 31597593
AN - SCOPUS:85073032144
VL - 25
SP - 967
EP - 979
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
SN - 1471-4914
IS - 11
ER -