Microfluidic technology as an emerging clinical tool to evaluate thrombosis and hemostasis

Brian R. Branchford; Christopher J. Ng; Keith B. Neeves; Jorge Di Paola

doi:10.1016/j.thromres.2015.05.012

Microfluidic technology as an emerging clinical tool to evaluate thrombosis and hemostasis

Brian R. Branchford, Christopher J. Ng, Keith B. Neeves, Jorge Di Paola

Research output: Contribution to journal › Review article › peer-review

62 Scopus citations

Abstract

Assessment of platelet function and coagulation under flow conditions can augment traditional static assays used to evaluate patients with suspected hemostatic or thrombotic disorders. Among the available flow-based assays, microfluidic devices require the smallest blood volume and provide multiple output options. These assays are based on the presence of wall shear stress that mimics in vivo interactions between blood components and vessel walls. Microfluidic devices can generate essential information regarding homeostatic regulation of platelet activation and subsequent engagement of the coagulation cascade leading to fibrin deposition and clot formation. Emerging data suggest that microfluidic assays may also reveal consistent patterns of hemostatic or thrombotic pathology, and could aid in assessing and monitoring patient-specific effects of coagulation-modifying therapies.

Original language	English
Pages (from-to)	13-19
Number of pages	7
Journal	Thrombosis Research
Volume	136
Issue number	1
DOIs	https://doi.org/10.1016/j.thromres.2015.05.012
State	Published - Jul 1 2015

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title = "Microfluidic technology as an emerging clinical tool to evaluate thrombosis and hemostasis",

abstract = "Assessment of platelet function and coagulation under flow conditions can augment traditional static assays used to evaluate patients with suspected hemostatic or thrombotic disorders. Among the available flow-based assays, microfluidic devices require the smallest blood volume and provide multiple output options. These assays are based on the presence of wall shear stress that mimics in vivo interactions between blood components and vessel walls. Microfluidic devices can generate essential information regarding homeostatic regulation of platelet activation and subsequent engagement of the coagulation cascade leading to fibrin deposition and clot formation. Emerging data suggest that microfluidic assays may also reveal consistent patterns of hemostatic or thrombotic pathology, and could aid in assessing and monitoring patient-specific effects of coagulation-modifying therapies.",

author = "Branchford, {Brian R.} and Ng, {Christopher J.} and Neeves, {Keith B.} and {Di Paola}, Jorge",

note = "Funding Information: This work was supported by the National Hemophilia Foundation/Baxter Clinical Research Fellowship (B.B. and C.N.), American Society of Hematology Scholar Award (B.B.), Hemostasis and Thrombosis Research Society Mentored Research Award (B.B. and C.N.), CSL Behring/Prof. Heimburger Award in Hemostas is (B.B.), NIH K12HD068372-03 Child Health Research Career Development grant (B.B.), NIH R01 HL084086 (J.D.), NSF CAREER (K.N.), AHA 14GRNT20410094 (K.N.), Bayer Hemophilia Awards Program (K.N.), and NIH R01HL120728 (J.D, K.N.). Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

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doi = "10.1016/j.thromres.2015.05.012",

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AU - Branchford, Brian R.

AU - Ng, Christopher J.

AU - Neeves, Keith B.

AU - Di Paola, Jorge

N1 - Funding Information: This work was supported by the National Hemophilia Foundation/Baxter Clinical Research Fellowship (B.B. and C.N.), American Society of Hematology Scholar Award (B.B.), Hemostasis and Thrombosis Research Society Mentored Research Award (B.B. and C.N.), CSL Behring/Prof. Heimburger Award in Hemostas is (B.B.), NIH K12HD068372-03 Child Health Research Career Development grant (B.B.), NIH R01 HL084086 (J.D.), NSF CAREER (K.N.), AHA 14GRNT20410094 (K.N.), Bayer Hemophilia Awards Program (K.N.), and NIH R01HL120728 (J.D, K.N.). Publisher Copyright: © 2015 Elsevier Ltd.

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N2 - Assessment of platelet function and coagulation under flow conditions can augment traditional static assays used to evaluate patients with suspected hemostatic or thrombotic disorders. Among the available flow-based assays, microfluidic devices require the smallest blood volume and provide multiple output options. These assays are based on the presence of wall shear stress that mimics in vivo interactions between blood components and vessel walls. Microfluidic devices can generate essential information regarding homeostatic regulation of platelet activation and subsequent engagement of the coagulation cascade leading to fibrin deposition and clot formation. Emerging data suggest that microfluidic assays may also reveal consistent patterns of hemostatic or thrombotic pathology, and could aid in assessing and monitoring patient-specific effects of coagulation-modifying therapies.

AB - Assessment of platelet function and coagulation under flow conditions can augment traditional static assays used to evaluate patients with suspected hemostatic or thrombotic disorders. Among the available flow-based assays, microfluidic devices require the smallest blood volume and provide multiple output options. These assays are based on the presence of wall shear stress that mimics in vivo interactions between blood components and vessel walls. Microfluidic devices can generate essential information regarding homeostatic regulation of platelet activation and subsequent engagement of the coagulation cascade leading to fibrin deposition and clot formation. Emerging data suggest that microfluidic assays may also reveal consistent patterns of hemostatic or thrombotic pathology, and could aid in assessing and monitoring patient-specific effects of coagulation-modifying therapies.

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Microfluidic technology as an emerging clinical tool to evaluate thrombosis and hemostasis

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