TY - GEN
T1 - Microfluidic cardiac circulation model (μCCM) for functional cardiomyocyte studies
AU - Nguyen, Mai Dung
AU - Giridharan, Guruprasad
AU - Prabhu, Sumanth D.
AU - Sethu, Palaniappan
PY - 2009
Y1 - 2009
N2 - Physiological heart development and cardiac function rely on the response of cardiomyocytes to mechanical stress signals during hemodynamic loading and unloading. These stresses manifest themselves via changes in cell structure, contractile function and gene expression. Disruption of this well balanced stress-sensing machinery due to various pathological conditions results in contractile dysfunction, cardiac remodeling and heart failure. In order to study signaling mechanisms involved in the pathogenesis of various manifestations of Cardiovascular Disease (CVD), there is a need for physiologically relevant in-vitro models. To accomplish this goal, we have developed a Microfluidic Cardiac Circulation Model (μCCM) that integrates mechanically loaded cardiomyocytes with fluid flow and a circulation network.
AB - Physiological heart development and cardiac function rely on the response of cardiomyocytes to mechanical stress signals during hemodynamic loading and unloading. These stresses manifest themselves via changes in cell structure, contractile function and gene expression. Disruption of this well balanced stress-sensing machinery due to various pathological conditions results in contractile dysfunction, cardiac remodeling and heart failure. In order to study signaling mechanisms involved in the pathogenesis of various manifestations of Cardiovascular Disease (CVD), there is a need for physiologically relevant in-vitro models. To accomplish this goal, we have developed a Microfluidic Cardiac Circulation Model (μCCM) that integrates mechanically loaded cardiomyocytes with fluid flow and a circulation network.
UR - http://www.scopus.com/inward/record.url?scp=84903863137&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2009.5334997
DO - 10.1109/IEMBS.2009.5334997
M3 - Conference contribution
C2 - 19965137
AN - SCOPUS:84903863137
SN - 9781424432967
T3 - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
SP - 1060
EP - 1063
BT - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
T2 - 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Y2 - 2 September 2009 through 6 September 2009
ER -