Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effectsin vivo

Michelle D. Combs, Russell H. Knutsen, Thomas J. Broekelmann, Holly M. Toennies, Thomas J. Brett, Chantel A. Miller, Daniel L. Kober, Clarissa S. Craft, Jeffrey J. Atkinson, J. Michael Shipley, Barbara C. Trask, Robert P. Mecham

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Background:The function of MAGP2 was studied by inactivating its gene (Mfap5-/-) in mice. Results:Mfap5-/- mice have a neutrophil deficiency and other phenotypes that are different from MAGP1- and fibrillindeficient animals. Conclusion:MAGP2 has functional roles in hematopoiesis and in vessel wall maintenance. Significance:Characterization of MAGP2 function is crucial to the identification and treatment of microfibril-related disease.

Original languageEnglish
Pages (from-to)28869-28880
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number40
DOIs
StatePublished - Oct 4 2013

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