TY - JOUR
T1 - Microcirculation of intramyocardial hemorrhage caused by reperfused myocardial infarctions with ultrasmall superparamagnetic iron oxide cardiac magnetic resonance imaging
AU - Xia, Rui
AU - Zhu, Tong
AU - Zhang, Yu
AU - He, Bo
AU - Wang, Lei
AU - Zheng, Jie
AU - Gao, Fabao
N1 - Funding Information:
USPIO was kindly provided by Dr Lili Yang (Department of Surgery, Emory University School of Medicine, Atlanta, GA, United States). The author(s) received the following financial support for the research, authorship, and/or publication of this article: This study was supported by The National Natural Science Foundation of China (81601546, 81520108014, 81771800, 81829003).
Funding Information:
The author(s) received the following financial support for the research, authorship, and/or publication of this article: This study was supported by The National Natural Science Foundation of China (81601546, 81520108014, 81771800, 81829003).
Publisher Copyright:
© The Foundation Acta Radiologica 2021.
PY - 2022/11
Y1 - 2022/11
N2 - Background: The actual role of the coronary microcirculation, which is massively injured by myocardial infarction (MI), in intramyocardial hemorrhage (IMH) pathophysiology is still not fully understood. Purpose: To determine the change and distribution of microcirculation of myocardial edema (ME), IMH, MI, and the remote area of early reperfusion using 7.0-T cardiovascular magnetic resonance (CMR) in a rat model of acute MI. Material and Methods: Eight rats with 60-min myocardial ischemia followed by reperfusion were investigated. On days 2 and 7, after the acquisition of T2*-mapping and T2-mapping images, late gadolinium enhancement imaging was performed to evaluate the extent of myocardial ischemia after an injection of Gd-DTPA. On days 3 and 8, after the injection of ultrasmall superparamagnetic iron oxide (USPIO), T2*- and T2-mapping images were acquired. The R2 values of ME, IMH, MI, and remote areas were measured. Results: From days 2 to 3, R2 values increased in the IMH, MI, ME, and remote area (all P < 0.05) following administration of USPIO, while the delta R2 value of IMH and MI was larger than remote area (P < 0.05). From day 7 to day 8, there was no significant difference in the IMH, MI, ME, and remote area (all P > 0.05). Conclusion: Microvascular injury of IMH and MI is the most severe among all the studied myocardial injuries in the early reperfusion of MI, while microvascular density decreased during follow-up.
AB - Background: The actual role of the coronary microcirculation, which is massively injured by myocardial infarction (MI), in intramyocardial hemorrhage (IMH) pathophysiology is still not fully understood. Purpose: To determine the change and distribution of microcirculation of myocardial edema (ME), IMH, MI, and the remote area of early reperfusion using 7.0-T cardiovascular magnetic resonance (CMR) in a rat model of acute MI. Material and Methods: Eight rats with 60-min myocardial ischemia followed by reperfusion were investigated. On days 2 and 7, after the acquisition of T2*-mapping and T2-mapping images, late gadolinium enhancement imaging was performed to evaluate the extent of myocardial ischemia after an injection of Gd-DTPA. On days 3 and 8, after the injection of ultrasmall superparamagnetic iron oxide (USPIO), T2*- and T2-mapping images were acquired. The R2 values of ME, IMH, MI, and remote areas were measured. Results: From days 2 to 3, R2 values increased in the IMH, MI, ME, and remote area (all P < 0.05) following administration of USPIO, while the delta R2 value of IMH and MI was larger than remote area (P < 0.05). From day 7 to day 8, there was no significant difference in the IMH, MI, ME, and remote area (all P > 0.05). Conclusion: Microvascular injury of IMH and MI is the most severe among all the studied myocardial injuries in the early reperfusion of MI, while microvascular density decreased during follow-up.
KW - Microcirculation
KW - intramyocardial hemorrhage
KW - magnetic resonance imaging
KW - myocardial infarction
KW - ultrasmall superparamagnetic iron oxide
UR - http://www.scopus.com/inward/record.url?scp=85117412708&partnerID=8YFLogxK
U2 - 10.1177/02841851211046332
DO - 10.1177/02841851211046332
M3 - Article
C2 - 34668808
AN - SCOPUS:85117412708
VL - 63
SP - 1469
EP - 1474
JO - Acta Radiologica
JF - Acta Radiologica
SN - 0284-1851
IS - 11
ER -