@article{ceac9caac708473883751bec9bd809ea,
title = "Microbiota regulation of viral infections through interferon signaling",
abstract = "The interferon (IFN) response is the major early innate immune response against invading viral pathogens and is even capable of mediating sterilizing antiviral immunity without the support of the adaptive immune system. Cumulative evidence suggests that the gut microbiota can modulate IFN responses, indirectly determining virological outcomes. This review outlines our current knowledge of the interactions between the gut microbiota and IFN responses and dissects the different mechanisms by which the gut microbiota may alter IFN expression to diverse viral infections. This knowledge offers a basis for translating experimental evidence from animal studies into the human context and identifies avenues for leveraging the gut microbiota–IFN–virus axis to improve control of viral infections and performance of viral vaccines.",
keywords = "antiviral immunity, bacterial metabolites, gut microbiota, interferon-α/β, interferon-λ, viral infection",
author = "Wirusanti, {Nurul I.} and Baldridge, {Megan T.} and Harris, {Vanessa C.}",
note = "Funding Information: N.I.W. would like to thank A.K. Fajrial for valuable discussion and input for figures. M.T.B. was supported by NIH grants R01 OD024917, R01 AI141716, R01AI139314, and R01 AI141478, the Pew Biomedical Scholars Program of the Pew Charitable Trusts, and the Children's Discovery Institute of St Louis Children's Hospital and Washington University (MI-II-2019-790). V.C.H. was supported by The Netherlands Organization for Health Research and Development (ZonMw) VENI 09150161810022 and 10430022010019, Health Holland TKI GLORIA fund, and Wellcome Trust 219775/Z/19/Z. The funders had no role in the decision to publish or the preparation of the manuscript. No interests are declared. Funding Information: N.I.W. would like to thank A.K. Fajrial for valuable discussion and input for figures. M.T.B. was supported by NIH grants R01 OD024917 , R01 AI141716 , R01AI139314 , and R01 AI141478 , the Pew Biomedical Scholars Program of the Pew Charitable Trusts , and the Children{\textquoteright}s Discovery Institute of St Louis Children{\textquoteright}s Hospital and Washington University ( MI-II-2019-790 ). V.C.H. was supported by The Netherlands Organization for Health Research and Development (ZonMw) VENI 09150161810022 and 10430022010019 , Health Holland TKI GLORIA fund, and Wellcome Trust 219775/Z/19/Z . The funders had no role in the decision to publish or the preparation of the manuscript. Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
month = aug,
doi = "10.1016/j.tim.2022.01.007",
language = "English",
volume = "30",
pages = "778--792",
journal = "Trends in Microbiology",
issn = "0966-842X",
number = "8",
}