TY - JOUR
T1 - Microbiome restoration by RBX2660 does not preclude recurrence of multidrug-resistant urinary tract infection following subsequent antibiotic exposure
T2 - A case report
AU - Keen, Eric C.
AU - Tasoff, Preston
AU - Hink, Tiffany
AU - Reske, Kimberly A.
AU - Burnham, Carey Ann D.
AU - Dantas, Gautam
AU - Kwon, Jennie H.
AU - Dubberke, Erik R.
N1 - Publisher Copyright:
© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - A 62-year-old woman received RBX2660, an investigational microbiome restoration therapeutic, for recurrent multidrug-resistant (MDR) urinary tract infection (UTI). RBX2660 increased gut microbiome diversity but did not eliminate uropathogen carriage, and MDR UTI recurred after subsequent antibiotic exposure. Thus, restoration of microbiome diversity does not preclude disease recurrence by residual MDR pathogens.
AB - A 62-year-old woman received RBX2660, an investigational microbiome restoration therapeutic, for recurrent multidrug-resistant (MDR) urinary tract infection (UTI). RBX2660 increased gut microbiome diversity but did not eliminate uropathogen carriage, and MDR UTI recurred after subsequent antibiotic exposure. Thus, restoration of microbiome diversity does not preclude disease recurrence by residual MDR pathogens.
KW - Antibiotic resistance
KW - Fecal microbiota transplant
KW - Microbial restoration therapy
KW - Microbiome
KW - Urinary tract infection
UR - https://www.scopus.com/pages/publications/85087399884
U2 - 10.1093/ofid/ofaa042
DO - 10.1093/ofid/ofaa042
M3 - Article
C2 - 32154322
AN - SCOPUS:85087399884
SN - 2328-8957
VL - 7
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
IS - 3
M1 - ofaa042
ER -