Microbiome restoration by RBX2660 does not preclude recurrence of multidrug-resistant urinary tract infection following subsequent antibiotic exposure: A case report

Eric C. Keen, Preston Tasoff, Tiffany Hink, Kimberly A. Reske, Carey Ann D. Burnham, Gautam Dantas, Jennie H. Kwon, Erik R. Dubberke

Research output: Contribution to journalArticle

Abstract

A 62-year-old woman received RBX2660, an investigational microbiome restoration therapeutic, for recurrent multidrug-resistant (MDR) urinary tract infection (UTI). RBX2660 increased gut microbiome diversity but did not eliminate uropathogen carriage, and MDR UTI recurred after subsequent antibiotic exposure. Thus, restoration of microbiome diversity does not preclude disease recurrence by residual MDR pathogens.

Original languageEnglish
Article numberofaa042
JournalOpen Forum Infectious Diseases
Volume7
Issue number3
DOIs
StatePublished - 2020

Keywords

  • Antibiotic resistance
  • Fecal microbiota transplant
  • Microbial restoration therapy
  • Microbiome
  • Urinary tract infection

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