TY - JOUR
T1 - Microbiome in parturition and preterm birth
AU - Mysorekar, Indira U.
AU - Cao, Bin
PY - 2014/1
Y1 - 2014/1
N2 - Preterm parturition is a one of the most significant global maternal-child health problem. In recent years, there has been an explosion in reports on a role for microbiomes (i.e., a microbial biomass) on a plethora of physiologic and pathologic human conditions. This review aims to describe our current understanding of the microbiome and its impact on parturition, with particular emphasis on preterm birth. We will focus on the roles of vaginal and oral mucosal microbiomes in premature parturition and describe the state-of-the-art methodologies used in microbiome studies. Next, we will present new studies on a potential microbiome in the placenta and how it may affect pregnancy outcomes. Finally, we will propose that host genetic factors can perturb the normal "pregnancy microbiome" and trigger adverse pregnancy outcomes.
AB - Preterm parturition is a one of the most significant global maternal-child health problem. In recent years, there has been an explosion in reports on a role for microbiomes (i.e., a microbial biomass) on a plethora of physiologic and pathologic human conditions. This review aims to describe our current understanding of the microbiome and its impact on parturition, with particular emphasis on preterm birth. We will focus on the roles of vaginal and oral mucosal microbiomes in premature parturition and describe the state-of-the-art methodologies used in microbiome studies. Next, we will present new studies on a potential microbiome in the placenta and how it may affect pregnancy outcomes. Finally, we will propose that host genetic factors can perturb the normal "pregnancy microbiome" and trigger adverse pregnancy outcomes.
KW - bacteria
KW - microbiome
KW - parturition
KW - pregnancy
KW - preterm birth
UR - http://www.scopus.com/inward/record.url?scp=84891787332&partnerID=8YFLogxK
U2 - 10.1055/s-0033-1361830
DO - 10.1055/s-0033-1361830
M3 - Article
C2 - 24390921
AN - SCOPUS:84891787332
SN - 1526-8004
VL - 32
SP - 50
EP - 55
JO - Seminars in Reproductive Medicine
JF - Seminars in Reproductive Medicine
IS - 1
ER -