Microbiome control of innate reactivity

Feidi Chen, Thaddeus S. Stappenbeck

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Numerous scientific disciplines, including immunology, are now positioned to fully realize the potential of the intestinal microbiome to modulate a wide array of basic processes. Increasingly, microbiota-derived metabolites are being recognized for mediating these effects. Coupled with advances in large scale sequencing and mass spectrometry, research into the microbiota and their metabolites has entered into an era of rapid discovery. Here, we review recent studies that have shown how-specific metabolic products of the microbiome alter properties of the innate immune system that in turn modulate response to infection and immunity.

Original languageEnglish
Pages (from-to)107-113
Number of pages7
JournalCurrent Opinion in Immunology
StatePublished - Feb 2019


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