TY - JOUR
T1 - Microbiome control of innate reactivity
AU - Chen, Feidi
AU - Stappenbeck, Thaddeus S.
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2019/2
Y1 - 2019/2
N2 - Numerous scientific disciplines, including immunology, are now positioned to fully realize the potential of the intestinal microbiome to modulate a wide array of basic processes. Increasingly, microbiota-derived metabolites are being recognized for mediating these effects. Coupled with advances in large scale sequencing and mass spectrometry, research into the microbiota and their metabolites has entered into an era of rapid discovery. Here, we review recent studies that have shown how-specific metabolic products of the microbiome alter properties of the innate immune system that in turn modulate response to infection and immunity.
AB - Numerous scientific disciplines, including immunology, are now positioned to fully realize the potential of the intestinal microbiome to modulate a wide array of basic processes. Increasingly, microbiota-derived metabolites are being recognized for mediating these effects. Coupled with advances in large scale sequencing and mass spectrometry, research into the microbiota and their metabolites has entered into an era of rapid discovery. Here, we review recent studies that have shown how-specific metabolic products of the microbiome alter properties of the innate immune system that in turn modulate response to infection and immunity.
UR - http://www.scopus.com/inward/record.url?scp=85060235134&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2018.12.003
DO - 10.1016/j.coi.2018.12.003
M3 - Review article
C2 - 30677624
AN - SCOPUS:85060235134
SN - 0952-7915
VL - 56
SP - 107
EP - 113
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
ER -