@inbook{06124182cf3a48c3b3c38d7b3b187403,
title = "Microbial Production of High-Performance Fibers from Muscle Protein Titin",
abstract = "Nature has produced a variety of proteinaceous materials, each with a set of mechanical properties tuned by evolution to adapt to particular environments. While these advantageous properties have also made many of these materials well-suited to various human needs, few protein materials can be harvested from their natural hosts at scale. To meet the demand for these materials using scalable biomanufacturing processes, our lab has developed tools and a biopolymerization platform for the microbial synthesis and processing of nature-derived, high-molecular-weight protein polymers. In this chapter, we describe the application of this platform for polymerizing a segment of the muscle protein titin and processing the resulting polymer into high-performance, muscle-mimetic fibers with a unique combination of desirable mechanical properties.",
keywords = "In vivo polymerization, Protein materials, Synthetic biology",
author = "Sargent, \{Cameron J.\} and Bowen, \{Christopher H.\} and Fuzhong Zhang",
note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2025.",
year = "2025",
doi = "10.1007/978-1-0716-4402-7\_10",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "161--172",
booktitle = "Methods in Molecular Biology",
}