Microbial influences on the small intestinal response to radiation injury

Christopher D. Packey, Matthew A. Ciorba

Research output: Contribution to journalReview article

66 Scopus citations

Abstract

Purpose of review: Injury to the small bowel from ionizing radiation occurs commonly in patients undergoing cancer therapy and less commonly in instances of accidental radiation overexposure. Several lines of evidence now suggest that dynamic interactions between the host's enteric microbiota and innate immune system are important in modulating the intestinal response to radiation. Here, we will review recent developments in the area of acute radiation enteropathy and examine the current state of knowledge regarding the impact of host-microbial interactions in the process. Recent findings: There is promise in the development and testing of new clinical biomarkers including serum citrulline. Toll-like receptor agonists and innate immune system signaling pathways including nuclear factor-kappa B profoundly alter intestinal epithelial cell apoptosis and crypt survival after radiation exposure. Germ-free conditions, probiotics and antibiotics are each identified as modifiers of disease development and course. A human study suggested that luminal microbiota composition may influence the host's intestinal response to radiation and may change in those developing postradiation diarrhea. Summary: New knowledge implies that investigations aimed at deciphering the microbiome-host interactions before and after small bowl radiation injury may eventually allow prediction of disease course and offer opportunities for the development of novel therapeutic or prophylactic strategies.

Original languageEnglish
Pages (from-to)88-94
Number of pages7
JournalCurrent opinion in gastroenterology
Volume26
Issue number2
DOIs
StatePublished - Mar 1 2010

Keywords

  • Antibiotic
  • Innate immune
  • Microbiome
  • Probiotic
  • Radiation enteritis
  • Radiation enteropathy

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