Microbial copper-binding siderophores at the host-pathogen interface

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Abstract

Numerous pathogenic microorganisms secrete small molecule chelators called siderophores defined by their ability to bind extracellular ferric iron, making it bioavailable to microbes. Recently, a siderophore produced by uropathogenic Escherichia coli, yersiniabactin, was found to also bind copper ions during human infections. The ability of yersiniabactin to protect E. coli from copper toxicity and redox-based phagocyte defenses distinguishes it from other E. coli siderophores. Here we compare yersiniabactin to other extracellular copper-binding molecules and review how copper-binding siderophores may confer virulence-associated gains of function during infection pathogenesis.

Original languageEnglish
Pages (from-to)18967-18974
Number of pages8
JournalJournal of Biological Chemistry
Volume290
Issue number31
DOIs
StatePublished - Jul 31 2015

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