Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis

Medicine and Dentistry

• Hirschsprung's Disease 100%
• Spermiogenesis 100%
• Parasympathetic Nervous System 66%
• Small Intestine 33%
• Developmental Abnormality 33%
• Programmed Cell Death 33%
• Maturation 33%
• Phosphotransferase 33%
• Renal Agenesis 33%
• Testes 33%
• Seminiferous Tubule 33%
• Glial Cell Line Derived Neurotrophic Factor 33%
• Sympathetic Nervous System 33%
• Protein Kinase B 33%
• Kidney Hypoplasia 33%
• Gastric Dysmotility 33%
• Aganglionosis 33%
• Protein Ret 33%
• Germ Cell 33%
• Diseases 33%
• Nerve Fiber 33%
• Knockout Mouse 33%

Biochemistry, Genetics and Molecular Biology

• Spermatogenesis 100%
• Phenocopy 100%
• Germ Cell 50%
• Knockout Mouse 50%
• Wild Type 50%
• Kinase 50%
• Phosphotransferase 50%
• Receptor Tyrosine Kinase 50%
• Maturation 50%
• Small Intestine 50%
• Seminiferous Tubule 50%
• Protein Kinase B 50%
• Glial Cell Line-Derived Neurotrophic Factor 50%
• Programmed Cell Death 50%

Keyphrases

• Early Spermatogenesis 33%