MHC-restricted, glycopeptide-specific T cells show specificity for both carbohydrate and peptide residues

M. Brian Deck, Petter Sjölin, Emil R. Unanue, Jan Kihlberg

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

We examined the antigenic specificity of two T cell hybridomas elicited against the disaccharide galabiose attached to the fifth residue of the I- A(k) binding peptide 52-61 of lysozyme. By making changes in the saccharide molecule arid in the peptide, we conclude that the outer galactose residue of the galabiose moiety is directly recognized by the T cells together with the exposed side chains of the peptide. The overall spatial display of this galactose moiety on the 52-61 peptide is likewise important.

Original languageEnglish
Pages (from-to)4740-4744
Number of pages5
JournalJournal of Immunology
Volume162
Issue number8
StatePublished - Apr 15 1999

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