We examined the antigenic specificity of two T cell hybridomas elicited against the disaccharide galabiose attached to the fifth residue of the I- A(k) binding peptide 52-61 of lysozyme. By making changes in the saccharide molecule arid in the peptide, we conclude that the outer galactose residue of the galabiose moiety is directly recognized by the T cells together with the exposed side chains of the peptide. The overall spatial display of this galactose moiety on the 52-61 peptide is likewise important.
|Number of pages||5|
|Journal||Journal of Immunology|
|State||Published - Apr 15 1999|