Abstract
We examined the antigenic specificity of two T cell hybridomas elicited against the disaccharide galabiose attached to the fifth residue of the I- A(k) binding peptide 52-61 of lysozyme. By making changes in the saccharide molecule arid in the peptide, we conclude that the outer galactose residue of the galabiose moiety is directly recognized by the T cells together with the exposed side chains of the peptide. The overall spatial display of this galactose moiety on the 52-61 peptide is likewise important.
Original language | English |
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Pages (from-to) | 4740-4744 |
Number of pages | 5 |
Journal | Journal of Immunology |
Volume | 162 |
Issue number | 8 |
DOIs | |
State | Published - Apr 15 1999 |