@inproceedings{2b86ad962bc0437e977783bac79b98b4,
title = "MethylCRF, an algorithm for estimating absolute methylation levels at single CpG resolution from methylation enrichment and restriction enzyme sequencing methods",
abstract = "We introduce MethylCRF, a novel Conditional Random Fields-based algorithm to integrate methylated DNA immunoprecipitation (MeDIP-seq) and methylationsensitive restriction enzyme (MRE-seq) sequencing data to predict DNA methylation levels at single CpG resolution. MethylCRF was benchmarked for accuracy against Infinium arrays, RRBS, whole-genome shotgun-bisulfite (WGBS) sequencing and locus specific-bisufite sequencing on the same DNA. MethylCRF transformation of MeDIP/MRE was equivalent to a biological replicate of WGBS in quantification, coverage and resolution, providing a lower cost and widely accessible strategy to create full methylomes.",
keywords = "Conditional Random Fields, DNA methylation, Epigenomics",
author = "Michael Stevens and Cheng, \{Jeffrey B.\} and Mingchao Xie and Costello, \{Joseph F.\} and Ting Wang",
year = "2013",
month = apr,
day = "3",
doi = "10.1007/978-3-642-37195-0\_23",
language = "English",
isbn = "9783642371943",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
pages = "266--268",
booktitle = "Research in Computational Molecular Biology - 17th Annual International Conference, RECOMB 2013, Proceedings",
note = "17th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2013 ; Conference date: 07-04-2013 Through 10-04-2013",
}