Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses

Erin M. Green, Gloria Mas, Nicolas L. Young, Benjamin A. Garcia, Or Gozani

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Methylation of histones is central to chromatin regulation, and thus previously unknown mechanisms regulating genome function can be revealed through the discovery of new histone methyl marks. Here we identify Set5 as the first histone H4 methyltransferase, which monomethylates the critical H4 lysine residues 5, 8 and 12 in budding yeast. Set5's enzymatic activity functions together with the global chromatin-modifying complexes COMPASS and NuA4 to regulate cell growth and stress responses.

Original languageEnglish
Pages (from-to)361-363
Number of pages3
JournalNature Structural and Molecular Biology
Volume19
Issue number3
DOIs
StatePublished - Mar 2012

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