TY - JOUR
T1 - Methods for the Quantitative Determination of Multiple, Specific Polychlorinated Dibenzo-p-dioxin and Dibenzofuran Isomers in Human Adipose Tissue in the Parts-per-Trillion Range. An Interlaboratory Study
AU - Albro, P. W.
AU - Crummett, W. B.
AU - Lamparski, L. L.
AU - Nestrick, T. J.
AU - Peters, T. L.
AU - Dupuy, A. E.
AU - Harless, R. L.
AU - McDaniel, D. D.
AU - Gross, M. L.
AU - Meehan, J. L.
AU - Weerasinghe, N. C.A.
AU - Hanson, M.
AU - Nygren, M.
AU - Rappe, C.
AU - Hileman, F. D.
AU - Wendling, J. M.
AU - Hilker, D.
AU - O'Keefe, P.
AU - Jason, C.
AU - Johnson, J. L.
AU - Smith, L. M.
AU - Stalling, D. L.
AU - Lau, B. P.Y.
AU - Ryan, J. J.
PY - 1985/11
Y1 - 1985/11
N2 - Eight different approaches were applied In eight analytical laboratories to the quantitative determination of four chlorinated dibenzo-p-dioxins (2,3,7,8-Cl4; 1,2,3,7,8-Cl5; 1,2,3,4,7,8-Cl8; and 1,2,3,4,6,7,8,9-Cl8) and three chlorinated dibenzofurans (2,3,7,8-Cl4; 2,3,4,7,8-Cl5; and 1,2,3,7,8,9-Cl6) in spiked samples of an extract of human adipose tissue. One aspect of this blind study was the inclusion of potential interferences (polychlorinated biphenyls, PCBs; chlorinated diphenyl ethers; chlorinated methoxybiphenyls; DDE; other Cl4, Cl5, and Cl6 chlorinated dibenzofurans; and 1,2,3,4- tetra-chlorodibenzo-p-dioxin). Levels of fortification (unknown to the participating laboratories) were In the 5–50 pptr (parts-per-trillion) range except for octachlorodlbenzo-p-dioxin (up to 500 pptr). Results Indicated that most of the tested procedures gave a high degree of qualitative reliability. Several aspects of quantification were Identified in which improvement is possible. No one method was found to be clearly superior to all others. A number of future research needs were identified to help ensure and improve quantitative reliability in multicomponent analysis at the parts-per-trillion level.
AB - Eight different approaches were applied In eight analytical laboratories to the quantitative determination of four chlorinated dibenzo-p-dioxins (2,3,7,8-Cl4; 1,2,3,7,8-Cl5; 1,2,3,4,7,8-Cl8; and 1,2,3,4,6,7,8,9-Cl8) and three chlorinated dibenzofurans (2,3,7,8-Cl4; 2,3,4,7,8-Cl5; and 1,2,3,7,8,9-Cl6) in spiked samples of an extract of human adipose tissue. One aspect of this blind study was the inclusion of potential interferences (polychlorinated biphenyls, PCBs; chlorinated diphenyl ethers; chlorinated methoxybiphenyls; DDE; other Cl4, Cl5, and Cl6 chlorinated dibenzofurans; and 1,2,3,4- tetra-chlorodibenzo-p-dioxin). Levels of fortification (unknown to the participating laboratories) were In the 5–50 pptr (parts-per-trillion) range except for octachlorodlbenzo-p-dioxin (up to 500 pptr). Results Indicated that most of the tested procedures gave a high degree of qualitative reliability. Several aspects of quantification were Identified in which improvement is possible. No one method was found to be clearly superior to all others. A number of future research needs were identified to help ensure and improve quantitative reliability in multicomponent analysis at the parts-per-trillion level.
UR - https://www.scopus.com/pages/publications/0022360143
U2 - 10.1021/ac00290a063
DO - 10.1021/ac00290a063
M3 - Article
C2 - 4073517
AN - SCOPUS:0022360143
SN - 0003-2700
VL - 57
SP - 2717
EP - 2725
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 13
ER -